Comparison 1.
Mortality
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 All studies | 28 | 1668 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.90 [0.75, 1.08] |
| 2 Parenteral nutrition | 9 | 465 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.53 [0.29, 0.98] |
| 2.1 Medical trials | 4 | 158 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.67 [0.28, 1.62] |
| 2.2 Surgical trials | 5 | 307 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.43 [0.18, 1.02] |
| 3 Enteral nutrition | 6 | 275 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.75 [0.47, 1.20] |
| 3.1 Medical trials | 5 | 215 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.81 [0.50, 1.33] |
| 3.2 Surgical trials | 1 | 60 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.29 [0.03, 2.41] |
| 4 Supplements | 13 | 928 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.03 [0.84, 1.27] |
| 4.1 Medical trials | 9 | 710 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.08 [0.87, 1.33] |
| 4.2 Surgical trials | 4 | 218 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.65 [0.25, 1.65] |
| 5 Medical trials | 18 | 1083 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.99 [0.82, 1.20] |
| 5.1 Parenteral nutrition | 4 | 158 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.67 [0.28, 1.62] |
| 5.2 Enteral nutrition | 5 | 215 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.81 [0.50, 1.33] |
| 5.3 Supplements | 9 | 710 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.08 [0.87, 1.33] |
| 6 Surgical trials | 10 | 585 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.49 [0.27, 0.89] |
| 6.1 Parenteral nutrition | 5 | 307 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.43 [0.18, 1.02] |
| 6.2 Enteral nutrition | 1 | 60 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.29 [0.03, 2.41] |
| 6.3 Supplements | 4 | 218 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.65 [0.25, 1.65] |
| 7 Alcoholic hepatitis | 7 | 300 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.78 [0.50, 1.21] |
| 7.1 Parenteral nutrition | 3 | 118 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.64 [0.25, 1.62] |
| 7.2 Enteral nutrition | 2 | 95 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.10 [0.61, 1.99] |
| 7.3 Supplements | 2 | 87 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.47 [0.18, 1.23] |
| 8 Cirrhosis | 9 | 349 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.52 [0.28, 0.97] |
| 8.1 Parenteral nutrition | 2 | 60 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.6 [0.08, 4.27] |
| 8.2 Enteral nutrition | 3 | 120 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.48 [0.19, 1.18] |
| 8.3 Supplements | 4 | 169 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.56 [0.22, 1.39] |
| 9 HCC | 6 | 673 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.15 [0.93, 1.42] |
| 9.1 Parenteral nutrition | 1 | 124 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.52 [0.19, 1.47] |
| 9.2 Enteral nutrition | 0 | 0 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 9.3 Supplements | 5 | 549 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.22 [0.98, 1.52] |
| 10 Abstracts excluded | 25 | 1348 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.73 [0.57, 0.92] |
| 10.1 Medical trials ‐ parenteral nutrition | 4 | 158 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.67 [0.28, 1.62] |
| 10.2 Surgical trials ‐ parenteral nutrition | 5 | 307 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.43 [0.18, 1.02] |
| 10.3 Medical trials ‐ enteral nutrition | 4 | 152 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.84 [0.51, 1.38] |
| 10.4 Surgical trials ‐ enteral nutrition | 1 | 60 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.29 [0.03, 2.41] |
| 10.5 Medical trials ‐ supplements | 8 | 477 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.82 [0.60, 1.12] |
| 10.6 Surgical trials ‐ supplements | 3 | 194 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.65 [0.25, 1.65] |
| 11 Surgical trials without transplant patients | 7 | 410 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.60 [0.30, 1.20] |
| 11.1 Parenteral nutrition | 3 | 214 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.46 [0.18, 1.17] |
| 11.2 Enteral nutrition | 1 | 60 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.29 [0.03, 2.41] |
| 11.3 Supplements | 3 | 136 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.50 [0.37, 5.98] |
| 12 Intent to treat ‐ best‐case scenario for intervention | 24 | 1539 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.73 [0.61, 0.86] |
| 12.1 Medical trials ‐ parenteral nutrition | 4 | 170 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.42 [0.19, 0.96] |
| 12.2 Surgical trials ‐ parenteral nutrition | 4 | 268 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.22 [0.10, 0.49] |
| 12.3 Medical trials ‐ enteral nutrition | 5 | 215 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.81 [0.50, 1.33] |
| 12.4 Surgical trials ‐ enteral nutrition | 1 | 64 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.25 [0.03, 2.12] |
| 12.5 Medical trials ‐ supplements | 8 | 690 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.91 [0.74, 1.12] |
| 12.6 Surgical trials ‐ supplements | 2 | 132 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.59 [0.23, 1.52] |
| 13 Intent to treat ‐ worst‐case scenario for intervention | 24 | 1539 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.18 [0.99, 1.40] |
| 13.1 Medical trials ‐ parenteral nutrition | 4 | 170 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.19 [0.56, 2.50] |
| 13.2 Surgical trials ‐ parenteral nutrition | 4 | 268 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.19 [0.63, 2.25] |
| 13.3 Medical trials ‐ enteral nutrition | 5 | 215 | Risk Ratio (M‐H, Fixed, 95% CI) | 0.81 [0.50, 1.33] |
| 13.4 Surgical trials ‐ enteral nutrition | 1 | 64 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.25 [0.37, 4.23] |
| 13.5 Medical trials ‐ supplements | 8 | 690 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.27 [1.03, 1.56] |
| 13.6 Surgical trials ‐ supplements | 2 | 132 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.22 [0.50, 2.96] |