Comparison 8.
Serum bilirubin
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 All studies | 10 | 450 | Mean Difference (IV, Fixed, 95% CI) | ‐1.91 [‐2.72, ‐1.11] |
| 2 Parenteral nutrition | 6 | 269 | Mean Difference (IV, Fixed, 95% CI) | ‐2.52 [‐3.45, ‐1.60] |
| 2.1 Medical trials | 3 | 106 | Mean Difference (IV, Fixed, 95% CI) | ‐2.86 [‐3.82, ‐1.89] |
| 2.2 Surgical trials | 3 | 163 | Mean Difference (IV, Fixed, 95% CI) | 1.32 [‐1.95, 4.59] |
| 3 Enteral nutrition (all medical trials) | 2 | 94 | Mean Difference (IV, Fixed, 95% CI) | ‐0.17 [‐2.63, 2.29] |
| 3.1 Medical trials | 2 | 94 | Mean Difference (IV, Fixed, 95% CI) | ‐0.17 [‐2.63, 2.29] |
| 3.2 Surgical trials | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 4 Supplements | 2 | 87 | Mean Difference (IV, Fixed, 95% CI) | 0.24 [‐2.03, 2.51] |
| 4.1 Medical trials | 2 | 87 | Mean Difference (IV, Fixed, 95% CI) | 0.24 [‐2.03, 2.51] |
| 4.2 Surgical trials | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 5 Medical trials | 7 | 287 | Mean Difference (IV, Fixed, 95% CI) | ‐2.13 [‐2.96, ‐1.30] |
| 5.1 Parenteral nutrition | 3 | 106 | Mean Difference (IV, Fixed, 95% CI) | ‐2.86 [‐3.82, ‐1.89] |
| 5.2 Enteral nutrition | 2 | 94 | Mean Difference (IV, Fixed, 95% CI) | ‐0.17 [‐2.63, 2.29] |
| 5.3 Supplements | 2 | 87 | Mean Difference (IV, Fixed, 95% CI) | 0.24 [‐2.03, 2.51] |
| 6 Surgical trials | 3 | 163 | Mean Difference (IV, Fixed, 95% CI) | 1.32 [‐1.95, 4.59] |
| 6.1 Parenteral nutrition | 3 | 163 | Mean Difference (IV, Fixed, 95% CI) | 1.32 [‐1.95, 4.59] |
| 6.2 Enteral nutrition | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 6.3 Supplements | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 7 Alcoholic hepatitis | 5 | 184 | Mean Difference (IV, Random, 95% CI) | ‐3.51 [‐7.20, 0.18] |
| 7.1 Parenteral nutrition | 2 | 66 | Mean Difference (IV, Random, 95% CI) | ‐6.41 [‐9.41, ‐3.40] |
| 7.2 Enteral nutrition | 1 | 31 | Mean Difference (IV, Random, 95% CI) | ‐5.90 [‐17.54, 5.74] |
| 7.3 Supplements | 2 | 87 | Mean Difference (IV, Random, 95% CI) | 0.24 [‐2.03, 2.51] |
| 8 Cirrhosis | 3 | 154 | Mean Difference (IV, Fixed, 95% CI) | ‐1.10 [‐2.08, ‐0.12] |
| 8.1 Parenteral nutrition | 1 | 40 | Mean Difference (IV, Fixed, 95% CI) | ‐1.60 [‐2.74, ‐0.46] |
| 8.2 Enteral nutrition | 1 | 63 | Mean Difference (IV, Fixed, 95% CI) | 0.10 [‐2.42, 2.62] |
| 8.3 Supplements | 1 | 51 | Mean Difference (IV, Fixed, 95% CI) | 0.60 [‐2.33, 3.53] |
| 9 HCC | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 9.1 Pareneral nutrition | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 9.2 Enteral nutrition | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 9.3 Supplements | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 10 Abstracts excluded | 9 | 387 | Mean Difference (IV, Fixed, 95% CI) | ‐2.15 [‐3.01, ‐1.30] |
| 10.1 Parenteral nutrition | 6 | 269 | Mean Difference (IV, Fixed, 95% CI) | ‐2.52 [‐3.45, ‐1.60] |
| 10.2 Enteral nutrition | 1 | 31 | Mean Difference (IV, Fixed, 95% CI) | ‐5.90 [‐17.54, 5.74] |
| 10.3 Supplements | 2 | 87 | Mean Difference (IV, Fixed, 95% CI) | 0.24 [‐2.03, 2.51] |
| 11 Intent to treat ‐ best‐case scenario for intervention (cannot do analyses for continuous variables) | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 11.1 Parenteral nutrition ‐ medical trials | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 11.2 Parenteral nutrition ‐ surgical trials | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 11.3 Enteral nutrition ‐ medical trials | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 11.4 Enteral nutrition ‐ surgical trials | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 11.5 Supplements ‐ medical trials | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 11.6 Supplements ‐ surgical trials | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 12 Intent to treat ‐ worst‐case scenario for intervention (cannot do analyses for continuous variables) | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 12.1 Parenteral nutrition ‐ medical trials | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 12.2 Parenteral nutrition ‐ surgical trials | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 12.3 Enteral nutrition ‐ medical trials | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 12.4 Enteral nutrition ‐ surgical trials | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 12.5 Supplements ‐ medical trials | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 12.6 Supplements ‐ surgical trials | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 13 Alcoholic liver disease | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 13.1 Parenteral nutrition | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 13.2 Enteral nutrition | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 13.3 Supplements | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 14 Non‐alcoholic liver disease | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 14.1 Parenteral nutrition | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 14.2 Enteral nutrition | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 14.3 Supplements | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |