. 2019 Sep 29;9(11):1880–1899. doi: 10.1002/2211-5463.12719

Table 1.

Screening up‐regulated and down‐regulated DEGs in COPD by integrated microarray

DEGs	Gene symbol
Up‐regulated (62 genes)	PIEZO2, INHBA, VCAM1, RSPO2, CD1C, HSD17B6, AQP3, APLNR, GPD1, EGR2, KCNA, SLC18A2, FRZB, PTGS2, OLR1, EDNRA, SHISA2, ELF5, LUM, CYSLTR1, BMP5, HPGDS, MS4A2, DCC, FOSB, HHIP, MSMB, CD200, AMPD1, ICOS, RTKN2, CD83, FABP4, ISLR, GPR174, SLAMF7, WIF1, CTSW, CHIT1, CPA3, BMP1, EGR3, CX3CR1, EGR1, TREM2, ATF3, ICAM4, C8B, NR4A3, CCL8, HAS2, C4BPA, ITGB6, HBEGF, AGTR2, SERPIND1, CEACAM5, SFRP2, SELE, HLA‐DRB1, HLA‐DRB5, FGG
Down‐regulated (77 genes)	IL1R2, CEACAM4, ST6GALNAC3, ITGA10, MERTK, FKBP5, CLEC4E, LAMB1, MGAM, RPS6KA2, FLT1, IRAK3, SULT1B1, AOX1, SH3PXD2B, RNASE2, IL18R1, CD163, IL1RL1, GRASP, MT1A, S100A12, MMP8, GLT1D1, TMTC1, S100A8, IL4R, IL18RAP, FLT3, ANPEP, MT1M, SIGLEC10, SPARCL1, SMAP2, TIMP4, ANGPTL1, HIF3A, PKHD1L1, LILRB3, FPR1, SLED1, LDLRAD3, FAM150B, FPR2, ZBTB16, GCA, ARG1, CXCR2P1, S100A9, TMEM204, TINAGL1, ABCC8, VCAN, APOLD1, DDIT4, ARRDC2, SERPINA3, PIK3R3, ADM, PNMT, BTNL9, CRISPLD2, SLCO2A1, VNN2, TUBB1, PSAT1, PPBP, DEFA4, AQP9, TTN, PDK4, MT1L, MT1X, ORM1, CHRM2, PTX3, EIF1AY

DEGs

Gene symbol

Up‐regulated (62 genes)

PIEZO2, INHBA, VCAM1, RSPO2, CD1C, HSD17B6, AQP3, APLNR, GPD1, EGR2, KCNA, SLC18A2, FRZB, PTGS2, OLR1, EDNRA, SHISA2, ELF5, LUM, CYSLTR1, BMP5, HPGDS, MS4A2, DCC, FOSB, HHIP, MSMB, CD200, AMPD1, ICOS, RTKN2, CD83, FABP4, ISLR, GPR174, SLAMF7, WIF1, CTSW, CHIT1, CPA3, BMP1, EGR3, CX3CR1, EGR1, TREM2, ATF3, ICAM4, C8B, NR4A3, CCL8, HAS2, C4BPA, ITGB6, HBEGF, AGTR2, SERPIND1, CEACAM5, SFRP2, SELE, HLA‐DRB1, HLA‐DRB5, FGG

Down‐regulated (77 genes)

IL1R2, CEACAM4, ST6GALNAC3, ITGA10, MERTK, FKBP5, CLEC4E, LAMB1, MGAM, RPS6KA2, FLT1, IRAK3, SULT1B1, AOX1, SH3PXD2B, RNASE2, IL18R1, CD163, IL1RL1, GRASP, MT1A, S100A12, MMP8, GLT1D1, TMTC1, S100A8, IL4R, IL18RAP, FLT3, ANPEP, MT1M, SIGLEC10, SPARCL1, SMAP2, TIMP4, ANGPTL1, HIF3A, PKHD1L1, LILRB3, FPR1, SLED1, LDLRAD3, FAM150B, FPR2, ZBTB16, GCA, ARG1, CXCR2P1, S100A9, TMEM204, TINAGL1, ABCC8, VCAN, APOLD1, DDIT4, ARRDC2, SERPINA3, PIK3R3, ADM, PNMT, BTNL9, CRISPLD2, SLCO2A1, VNN2, TUBB1, PSAT1, PPBP, DEFA4, AQP9, TTN, PDK4, MT1L, MT1X, ORM1, CHRM2, PTX3, EIF1AY