Table 2.

Screening 139 DEGs in COPD by integrated microarray. AveExpr, average expression; FDR, false discovery rate

Gene symbol	logFC	AveExpr	t	P‐value	FDR
IL1R2	−3.724170635	4.910345092	−14.57070196	5.24E−25	8.38E−21
CEACAM4	−1.546190038	3.289938835	−14.11578934	3.65E−24	2.92E−20
ST6GALNAC3	−1.509348297	4.115922297	−13.72934365	1.93E−23	1.03E−19
ITGA10	−1.304452408	4.156071544	−13.3424854	1.05E−22	4.18E−19
MERTK	−1.371100619	5.743922084	−13.22669655	1.74E−22	4.99E−19
FKBP5	−2.553152066	5.964790869	−13.21010646	1.87E−22	4.99E−19
CLEC4E	−2.102592383	3.712865442	−12.2724444	1.22E−20	2.44E−17
LAMB1	−1.236900341	6.51036255	−12.11282186	2.51E−20	4.31E−17
MGAM	−1.918275604	3.743487329	−12.0971852	2.69E−20	4.31E−17
RPS6KA2	−1.051171425	6.235125074	−11.99287281	4.32E−20	6.28E−17
FLT1	−1.43735859	5.302047032	−11.6588263	1.98E−19	2.43E−16
IRAK3	−1.440362949	5.407265256	−11.53504535	3.48E−19	3.71E−16
PIEZO2	1.165120322	5.154801689	11.4846069	4.38E−19	4.38E−16
SULT1B1	−1.966128566	3.712292447	−11.44142282	5.34E−19	5.02E−16
AOX1	−1.498003567	4.380016656	−10.80239392	1.02E−17	8.14E−15
SH3PXD2B	−1.360072374	4.796109196	−10.45348254	5.15E−17	3.92E−14
RNASE2	−2.214352488	3.502846585	−10.41707921	6.11E−17	4.44E−14
IL18R1	−1.552709013	4.479557525	−10.21566115	1.56E−16	1.04E−13
CD163	−2.353331128	6.483508901	−10.18905044	1.77E−16	1.13E−13
IL1RL1	−2.008254697	5.747865421	−10.06701534	3.13E−16	1.88E−13
INHBA	1.437565757	4.698423572	10.06451042	3.17E−16	1.88E−13
VCAM1	1.58323448	4.54949487	9.975765691	4.80E−16	2.74E−13
GRASP	−1.019125221	5.351837423	−9.953904434	5.32E−16	2.93E−13
RSPO2	1.22508185	4.281279622	9.943524241	5.59E−16	2.98E−13
CD1C	1.320908918	4.048138575	9.847836259	8.75E−16	4.51E−13
HSD17B6	1.611303762	5.543589418	9.811225763	1.04E−15	5.03E−13
MT1A	−2.003809136	5.341700669	−9.802106469	1.08E−15	5.10E−13
AQP3	1.465444106	6.255672988	9.709215286	1.68E−15	7.66E−13
S100A12	−2.381911789	3.793860618	−9.658062064	2.13E−15	9.26E−13
APLNR	1.462761779	4.060794485	9.514044214	4.19E−15	1.76E−12
GPD1	1.162408188	4.425391991	9.418745073	6.56E−15	2.65E−12
EGR2	1.7756242	5.312493191	9.415498145	6.66E−15	2.65E−12
MMP8	−1.963376342	1.850422771	−9.410996945	6.80E−15	2.65E−12
KCNA3	1.127720579	5.181587794	9.376872801	7.99E−15	2.98E−12
SLC18A2	1.155076678	4.861252305	9.375465524	8.04E−15	2.98E−12
GLT1D1	−1.354253187	4.134707596	−9.333414043	9.80E−15	3.33E−12
TMTC1	−1.221922174	4.907718006	−9.2268097	1.62E−14	5.28E−12
S100A8	−1.984436486	6.732435285	−9.226677546	1.62E−14	5.28E−12
IL4R	−1.016737627	6.13438495	−9.220088063	1.67E−14	5.34E−12
IL18RAP	−1.20706302	4.403623117	−9.181902429	2.00E−14	6.26E−12
FRZB	1.108947075	4.570621342	9.054280215	3.64E−14	1.08E−11
PTGS2	1.909599543	5.385732252	9.037623232	3.94E−14	1.14E−11
FLT3	−1.068728329	2.955444457	−9.011875495	4.44E−14	1.24E−11
OLR1	1.516024757	5.630156756	9.006280553	4.56E−14	1.24E−11
ANPEP	−1.451754311	4.687966342	−9.001861447	4.66E−14	1.24E−11
MT1M	−2.585708871	5.454959847	−8.990902454	4.90E−14	1.29E−11
SIGLEC10	−1.464287775	4.29164058	−8.960779525	5.65E−14	1.46E−11
EDNRA	1.016233852	5.691095587	8.939250683	6.25E−14	1.56E−11
SHISA2	1.00660372	5.288052754	8.886393339	8.02E−14	1.94E−11
SPARCL1	−1.096814178	7.567105051	−8.760826399	1.45E−13	3.30E−11
SMAP2	−1.030733342	6.515681918	−8.593715399	3.17E−13	6.73E−11
TIMP4	−1.656076369	4.229601784	−8.456527093	6.04E−13	1.19E−10
ELF5	1.521617319	4.673219557	8.448782695	6.26E−13	1.21E−10
ANGPTL1	−1.111036176	3.340161894	−8.413321275	7.39E−13	1.37E−10
HIF3A	−1.065614158	4.526630285	−8.386705336	8.38E−13	1.52E−10
PKHD1L1	−1.402091953	3.533210448	−8.281317436	1.37E−12	2.29E−10
LUM	1.008125744	6.388824425	8.261829056	1.50E−12	2.45E−10
CYSLTR1	1.017621995	4.334713339	8.231060286	1.74E−12	2.78E−10
LILRB3	−1.182035723	3.930324211	−8.201110624	2.00E−12	3.11E−10
FPR1	−1.497358339	5.123265733	−8.165184027	2.36E−12	3.63E−10
BMP5	1.082572	4.856866963	8.039056504	4.26E−12	6.14E−10
HPGDS	1.178976758	4.9661482	7.971057179	5.85E−12	8.07E−10
SLED1	−1.418643068	4.176703046	−7.93529438	6.92E−12	9.42E−10
MS4A2	1.127545704	4.501069641	7.934255426	6.95E−12	9.42E−10
DCC	1.107054924	4.066396917	7.874112823	9.20E−12	1.21E−9
LDLRAD3	−1.132183539	4.777010972	−7.827670594	1.14E−11	1.42E−9
FAM150B	−1.326763929	3.661484534	−7.801467295	1.29E−11	1.57E−9
FOSB	2.16754811	6.605909434	7.722677313	1.86E−11	2.20E−9
FPR2	−1.585779616	4.015151074	−7.702560188	2.04E−11	2.40E−9
ZBTB16	−1.704030574	5.808698383	−7.660799671	2.48E−11	2.87E−9
GCA	−1.036962474	4.831056628	−7.646120016	2.65E−11	3.03E−9
HHIP	1.361681455	6.338309941	7.624501498	2.93E−11	3.28E−9
CD200	1.045448111	4.105658515	7.579848564	3.61E−11	3.95E−9
ARG1	−1.363394352	2.024018729	−7.54254425	4.29E−11	4.60E−9
AMPD1	1.043721979	3.103940463	7.443735113	6.77E−11	6.85E−9
ICOS	1.222541378	4.277643563	7.41874473	7.59E−11	7.59E−9
CXCR2P1	−1.15616615	4.439580145	−7.399724607	8.29E−11	8.23E−9
S100A9	−1.545635339	5.747693368	−7.378920244	9.12E−11	9.01E−9
RTKN2	1.696929199	6.166705232	7.344341435	1.07E−10	1.03E−8
TMEM204	−1.048529786	6.26406167	−7.165974961	2.43E−10	2.11E−8
CD83	1.134658456	5.71435664	7.163495775	2.45E−10	2.12E−8
FABP4	1.58545563	4.778254935	7.12319994	2.95E−10	2.51E−8
TINAGL1	−1.026326535	5.532226715	−7.093847539	3.38E−10	2.84E−8
ABCC8	−1.278473261	3.740007718	−7.069781506	3.77E−10	3.09E−8
VCAN	−1.162194417	5.676393323	−7.050563618	4.11E−10	3.29E−8
ISLR	1.017944512	5.018753667	7.010420181	4.94E−10	3.80E−8
APOLD1	−1.385170588	5.098238511	−6.976021904	5.78E−10	4.35E−8
DDIT4	−1.34772118	5.257280573	−6.808572358	1.23E−9	8.33E−8
ARRDC2	−1.061269085	5.499220509	−6.762488227	1.52E−9	1.01E−7
GPR174	1.391314128	4.486280437	6.747714106	1.63E−9	1.07E−7
SERPINA3	−1.612709918	5.391772667	−6.745585747	1.64E−9	1.07E−7
PIK3R3	−1.190376757	5.660292101	−6.728449631	1.77E−9	1.14E−7
SLAMF7	1.083604552	4.392800911	6.727219831	1.78E−9	1.14E−7
WIF1	1.237156067	6.258872842	6.708747667	1.94E−9	1.24E−7
ADM	−1.075662424	5.196278444	−6.701236397	2.00E−9	1.28E−7
PNMT	−1.051631588	4.068574241	−6.553848929	3.88E−9	2.30E−7
CTSW	1.07957302	4.747480058	6.545368949	4.04E−9	2.38E−7
BTNL9	−1.132836349	5.578696855	−6.494296937	5.07E−9	2.82E−7
CHIT1	1.774209888	5.594573377	6.490067624	5.17E−9	2.87E−7
CRISPLD2	−1.078448778	5.7156417	−6.459148182	5.93E−9	3.26E−7
CPA3	1.002710147	5.278769406	6.398904433	7.75E−9	4.12E−7
BMP1	1.049814522	5.450758141	6.3426456	9.95E−9	5.12E−7
SLCO2A1	−1.051736858	6.743524273	−6.312993603	1.13E−8	5.69E−7
VNN2	−1.015536891	4.57616008	−6.274690529	1.34E−8	6.55E−7
TUBB1	−1.110536854	3.804924924	−6.264199999	1.41E−8	6.82E−7
PSAT1	−1.190066031	3.005323949	−6.258737184	1.44E−8	6.94E−7
EGR3	1.186935902	4.097335491	6.248573488	1.51E−8	7.22E−7
CX3CR1	1.284828947	5.212105592	6.144966898	2.38E−8	1.08E−6
EGR1	1.194905541	7.538328018	6.08564001	3.08E−8	1.35E−6
TREM2	1.128703086	3.987081843	6.03163178	3.90E−8	1.67E−6
ATF3	1.034162475	4.884273698	5.696410877	1.65E−7	5.92E−6
PPBP	−1.424569764	3.860588827	−5.646955582	2.04E−7	7.16E−6
ICAM4	1.390911425	5.019641081	5.625030952	2.24E−7	7.74E−6
DEFA4	−1.206319405	2.718323142	−5.614366702	2.34E−7	8.06E−6
C8B	1.199289417	3.724442441	5.595043977	2.54E−7	8.65E−6
NR4A3	1.153028606	4.646253713	5.56155394	2.93E−7	9.79E−6
CCL8	1.533954481	3.932933151	5.448623389	4.71E−7	1.48E−5
AQP9	−1.182290805	4.835881555	−5.430616006	5.08E−7	1.56E−5
HAS2	1.525864945	3.562127425	5.306311934	8.51E−7	2.44E−5
TTN	−1.043207507	3.817413024	−5.293238479	8.98E−7	2.56E−5
C4BPA	1.055176798	7.356691544	5.268476209	9.95E−7	2.79E−5
ITGB6	1.140444449	6.076736655	5.260091655	1.03E−6	2.86E−5
PDK4	−1.021408815	6.733080202	−5.134267178	1.72E−6	4.47E−5
HBEGF	1.032852155	5.680806271	5.061817586	2.31E−6	5.73E−5
MT1L	−1.182918274	2.526143932	−4.990697548	3.08E−6	7.38E−5
MT1X	−1.137570423	3.368378253	−4.974584006	3.29E−6	7.77E−5
AGTR2	1.364930071	3.524442993	4.842112874	5.57E−6	0.000119643
ORM1	−1.331793001	2.918107873	−4.800748967	6.56E−6	0.000138298
CHRM2	−1.011281909	2.379732249	−4.689445874	1.01E−5	0.000200001
SERPIND1	1.253485683	3.227485742	4.600275561	1.43E−5	0.000265554
CEACAM5	1.121861431	3.16229753	4.495719542	2.14E−5	0.000368719
SFRP2	1.129656517	4.14961175	4.486856217	2.21E−5	0.000377179
SELE	1.138034748	3.853029685	3.80214458	0.00026654	0.003035211
PTX3	−1.402248844	4.135304651	−3.574413207	0.000577009	0.005747801
HLA‐DRB1	2.096264176	4.01015487	3.496867141	0.000745469	0.007027456
HLA‐DRB5	2.134896841	3.007061623	3.473802838	0.000803932	0.007481531
EIF1AY	−1.506138016	3.020677733	−3.35747922	0.00117078	0.010029593
FGG	1.286056757	4.918716551	2.965432506	0.003905804	0.026040868
MSMB	1.936339164	3.146192242	2.931036227	0.00432076	0.028265267