Table 4.
KEGG pathway analysis of DEGs associated with COPD
| ID | Pathway | Gene count | Corrected P‐value | DEGs |
|---|---|---|---|---|
| hsa04640 | Hematopoietic cell lineage | 7 | 4.07E−6 | FLT3, IL4R, HLA‐DRB1, HLA‐DRB5, IL1R2, CD1C, ANPEP |
| hsa04060 | Cytokine‐cytokine receptor interaction | 10 | 4.07E−6 | FLT3, FLT1, CCL8, IL4R, INHBA, CX3CR1, IL1R2, IL18RAP, PPBP, IL18R1 |
| hsa05150 | Staphylococcus aureus infection | 5 | 0.000147 | HLA‐DRB1, FPR2, FGG, FPR1, HLA‐DRB5 |
| hsa05166 | Human T‐lymphotropic virus type 1 infection | 8 | 0.000174 | PIK3R3, HLA‐DRB1, ATF3, HLA‐DRB5, VCAM1, IL1R2, EGR2, EGR1 |
| hsa05321 | Inflammatory bowel disease | 5 | 0.000174 | HLA‐DRB1, IL18RAP, IL4R, HLA‐DRB5, IL18R1 |
| hsa04514 | Cell adhesion molecules | 6 | 0.000456 | SELE, HLA‐DRB1, ICOS, HLA‐DRB5, VCAM1, VCAN |
| hsa04151 | Phosphoinositide 3‐kinase‐Akt signaling pathway | 8 | 0.000732 | CHRM2, PIK3R3, ITGA10, IL4R, LAMB1, DDIT4, ITGB6, FLT1 |
| hsa05146 | Amoebiasis | 5 | 0.000732 | C8B, PIK3R3, ARG1, LAMB1, IL1R2 |
| hsa04668 | Tumor necrosis factor signaling pathway | 5 | 0.001006 | VCAM1, PIK3R3, SELE, PTGS2, IL18R1 |
| hsa04080 | Neuroactive ligand‐receptor interaction | 7 | 0.00112 | CHRM2, FPR2, AGTR2, APLNR, EDNRA, CYSLTR1, FPR1 |
| hsa05200 | Pathways in cancer | 8 | 0.001401 | DCC, FLT3, ZBTB16, LAMB1, PIK3R3, HHIP, PTGS2, EDNRA |
| hsa04614 | Renin‐angiotensin system | 3 | 0.00144 | CPA3, AGTR2, ANPEP |
| hsa04610 | Complement and coagulation cascades | 4 | 0.002727 | FGG, C8B, C4BPA, SERPIND1 |
| hsa05310 | Asthma | 3 | 0.003037 | HLA‐DRB1, HLA‐DRB5, MS4A2 |
| hsa00750 | Vitamin B6 metabolism | 2 | 0.003805 | PSAT1, AOX1 |
| hsa05202 | Transcriptional misregulation in cancer | 5 | 0.005115 | FLT3, ZBTB16, FLT1, NR4A3, IL1R2 |
| hsa04933 | AGE‐RAGE signaling pathway in diabetic complications | 4 | 0.005115 | VCAM1, PIK3R3, SELE, EGR1 |
| hsa04510 | Focal adhesion | 5 | 0.007653 | PIK3R3, ITGA10, ITGB6, LAMB1, FLT1 |
| hsa04672 | Intestinal immune network for IgA production | 3 | 0.007653 | HLA‐DRB1, ICOS, HLA‐DRB5 |
| hsa05145 | Toxoplasmosis | 4 | 0.007715 | HLA‐DRB1, PIK3R3, LAMB1, HLA‐DRB5 |
| hsa04978 | Mineral absorption | 3 | 0.007715 | MT1X, MT1A, MT1M |
| hsa04923 | Regulation of lipolysis in adipocytes | 3 | 0.009035 | PIK3R3, PTGS2, FABP4 |
| hsa05221 | Acute myeloid leukemia | 3 | 0.009074 | FLT3, ZBTB16, PIK3R3 |
| hsa04380 | Osteoclast differentiation | 4 | 0.009515 | LILRB3, PIK3R3, FOSB, TREM2 |
| hsa01100 | Metabolic pathways | 12 | 0.00997 | PSAT1, HPGDS, ARG1, ST6GALNAC3, AOX1, PNMT, HSD17B6, AMPD1, PTGS2, CHIT1, MGAM, ANPEP |
| hsa04145 | Phagosome | 4 | 0.015537 | HLA‐DRB1, TUBB1, HLA‐DRB5, OLR1 |
| hsa05140 | Leishmaniasis | 3 | 0.015831 | HLA‐DRB1, PTGS2, HLA‐DRB5 |
| hsa04512 | Extracellular matrix‐receptor interaction | 3 | 0.02016 | ITGA10, ITGB6, LAMB1 |
| hsa05410 | Hypertrophic cardiomyopathy | 3 | 0.02016 | TTN, ITGA10, ITGB6 |
| hsa05222 | Small‐cell lung cancer | 3 | 0.021463 | PIK3R3, PTGS2, LAMB1 |
| hsa05414 | Dilated cardiomyopathy | 3 | 0.023455 | TTN, ITGA10, ITGB6 |
| hsa05323 | Rheumatoid arthritis | 3 | 0.023455 | HLA‐DRB1, FLT1, HLA‐DRB5 |
| hsa04062 | Chemokine signaling pathway | 4 | 0.023572 | CX3CR1, PIK3R3, CCL8, PPBP |
| hsa04915 | Estrogen signaling pathway | 3 | 0.027527 | FKBP5, PIK3R3, HBEGF |
| hsa04024 | cAMP signaling pathway | 4 | 0.027527 | CHRM2, PIK3R3, HHIP, EDNRA |
| hsa04810 | Regulation of actin cytoskeleton | 4 | 0.032602 | CHRM2, PIK3R3, ITGA10, ITGB6 |
| hsa00350 | Tyrosine metabolism | 2 | 0.032602 | AOX1, PNMT |
| hsa05020 | Prion diseases | 2 | 0.032602 | C8B, EGR1 |
| hsa05143 | African trypanosomiasis | 2 | 0.032602 | VCAM1, SELE |
| hsa05330 | Allograft rejection | 2 | 0.038438 | HLA‐DRB1, HLA‐DRB5 |
| hsa04722 | Neurotrophin signaling pathway | 3 | 0.038438 | IRAK3, PIK3R3, RPS6KA2 |
| hsa05332 | Graft‐versus‐host disease | 2 | 0.042328 | HLA‐DRB1, HLA‐DRB5 |
| hsa04940 | Type I diabetes mellitus | 2 | 0.04503 | HLA‐DRB1, HLA‐DRB5 |
| hsa04973 | Carbohydrate digestion and absorption | 2 | 0.047746 | MGAM, PIK3R3 |
| hsa05322 | Systemic lupus erythematosus | 3 | 0.048708 | HLA‐DRB1, C8B, HLA‐DRB5 |
| hsa04930 | Type II diabetes mellitus | 2 | 0.049139 | ABCC8, PIK3R3 |
| hsa05144 | Malaria | 2 | 0.049139 | VCAM1, SELE |
| hsa05030 | Cocaine addiction | 2 | 0.049139 | SLC18A2, FOSB |