Fig. 3.

VX-11e alone and in combination with voreloxin decreased ERK activation. MOLM-14, K562, REH and MOLT-4 cells were incubated for 24 h with VX-11e and voreloxin alone or in combination. ERK activity was determined using the Muse MAPK Activation Dual Detection Kit. a Representative dot plots and b graph of ERK activation in MOLM-14, K562, REH and MOLT-4 cell lines. Each value is the mean ± SD of three independent experiments. *(p < 0.05), **(p < 0.01) versus control; #(p < 0.05), ^##(p < 0.01) versus VX-11e; ^$(p < 0.05), ^$$(p < 0.01) versus voreloxin