Fig. 7.

VX-11e in combination with voreloxin inhibited NF-κB translocation into the nucleus. a MOLM-14, b K562, c REH and d MOLT-4 cells were incubated for 24 h with VX-11e (VX) and voreloxin (VOR) alone or in combination. Cells were immunostained for NF-κB (red fluorescence) and the nuclei were stained blue with Hoechst 33342. Representative confocal images and box-and-whisker plots representing the number of NF-κB positive dots per nucleus from three independent experiments. Bar = 10 μm. The box, line and whiskers represent the quartiles, median and range of data (minimal and maximal values), respectively. *(p < 0.05), **(p < 0.01) versus control; ^#(p < 0.05), ^##(p < 0.01) versus VX-11e; ^$(p < 0.05), ^$$(p < 0.01) versus voreloxin (Color figure online)