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. 2019 Oct 31;10:4972. doi: 10.1038/s41467-019-12865-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — Structural and functional characteristics of the known conformations of the groove of Ca²⁺-bound nhTMEM16 scramblase. The groove conformations shown are (from left to right): Ca²⁺-bound closed (PDBID 6QMB¹⁸); intermediate (PDBID 6QMA¹⁸); ion-conductive (PDBID 6OY3, this study); membrane-exposed (PDBID 6QM9¹⁸); and lipid-conductive (obtained from MD simulations²¹). In all structures, TMs 3–6 are colored in red, blue, white, and silver, respectively, and are labeled