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. 2019 Oct 31;9:15741. doi: 10.1038/s41598-019-52299-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis workflow. Redox genes were selected from Gene Ontology and PeroxiBase and then manually curated (Node selection). Protein-protein interactions were obtained from STRING database, protein-chemical interactions were obtained from STITCH database, and the final network was handled using RedeR Bioconductor package (Network construction). The evolutionary root of each A. thaliana antioxidant gene was inferred using geneplast Bioconductor package (Evolutionary analysis).