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. 2019 Oct 31;9:15781. doi: 10.1038/s41598-019-51282-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The synapse and its core submodules. (A) A diagram of the bilaterian synapse, signal transmitting and receiving cells, top and bottom respectively. Synaptic genes present in Amphimedon queenslandica are shaded green; genes not present are grey. Gene products are clustered into synaptic functions (submodules) and outlined by colour: exocytosis, blue; endocytosis, red; cell surface signals and receptors, yellow; active zone, dark green; and post-synaptic scaffolding, purple; gene products not outlined do not comprise these five submodules. (B) Evidence-based interactome for the human synaptome based on a non-redundant merging of BioGrid, STRING and APID databases. Genes (nodes) and associated interactions (edges/connecting lines) falling under the five core synaptic submodules are coded with the same color scheme as in (A). Clustering coefficients (C) for these submodules are shown.