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. 2019 Oct 31;6:258. doi: 10.1038/s41597-019-0171-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Data generation. The behavioral/EEG end-phenotypes of the BXD mouse panel were quantified in Experiment 1. Mice were recorded for 4 days: 2 days of baseline (B1 & B2), followed by 6 h of sleep deprivation (SD) and 2 days of recovery (R1 & R2). EEG spectral composition was written in .smo files, activity in .act files and meta-data in .hdr files. Blood metabolomics, liver transcriptomics and cortical transcriptomics were quantified in Experiment 2. ‘Control’ and ‘Sleep deprived’ batches were sampled at a single time point: ZT6 (i.e. directly after sleep deprivation for the ‘sleep deprived’ batch). Transcriptomics was performed on pooled sampled per BXD strains. For blood metabolomics, metabolite quantification was performed for each BXD replicates. Adapted from².