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. 2019 Oct 31;9:15759. doi: 10.1038/s41598-019-52294-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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miRNA clusters and families analysis. (a) Up-regulated and (b) down-regulated miRNA clusters in Oct4+ hDFs. (c) Up-regulated and (d) down-regulated miRNA families in Oct4+ hDFs. (e) The Circos plot showing genomic locations and expression of miRNA clusters in Oct4+ and GFP+ hDFs. The outer circle represents chromosome ideogram as the reference for the genomic localization of individual miRNAs and clusters. Names of miRNA clusters are represented by name of the first miRNA molecule in a particular cluster. Clusters significantly up-regulated in Oct4+ hDFs are marked with two asterisks (**), clusters significantly down-regulated in Oct4+ hDFs are marked with one asterisk (*), (p < 0.05, Fold change(log2) > 1.5). The expression level of individual miRNAs (heatmap), miRNA clusters in Oct4+, and miRNA clusters in GFP+ hDFs are shown in the external, middle, and inner circles, respectively. The lines in the centre area represent interconnections between miRNA clusters and families. Red lines represent miRNA clusters that are also families.