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. 2019 Oct 31;9:15765. doi: 10.1038/s41598-019-52323-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Glycosuria and Sglt2 expression in Hnrnpf KO mice. (A) Urinary glucose in Ctrl and KO mice detected by dipstick test at the age of 6 weeks. (B) Longitudinal urinary glucose levels in male and female KO mice and Ctrl from the age of 6 weeks to 24 weeks measured by glucose colorimetric kit. Values are means ± SEM, n = 6. **P < 0.01; ***P < 0.005. KO versus Ctrl. ^##P < 0.01; ^###P < 0.005^, female KO versus male KO. IPGTT test in male and female (C) Ctrl and KO mice at the age of 23 weeks. (D) Ratio of Sglt2/Rpl13a mRNA expression quantified by RT-qPCR and (E) Representative WB of Sglt2 protein expression in male and female mouse RPTs at the age of 24 weeks. Values are means ± SEM, n = 6. ***P < 0.005; KO versus Ctrl. (F) Double immunostaining of Sglt2 and LTL (magnification x100) and semi-quantification of Sglt2/LTL immunostaining ratio (G) in male and female Ctrl and KO mouse kidneys at the age of 24 weeks. Values are Sglt2/LTL positive staining ratio, n = 6. ***P < 0.005, KO versus Ctrl.