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. 2019 Oct 31;9:15765. doi: 10.1038/s41598-019-52323-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of canagliflozin treatment on blood and urinary glucose levels, AGT and SGLT2 expression in mice. (A) SBP, (B) blood glucose and (C) urinary glucose levels after 4 weeks of treatment with or without canagliflozin in adult male and female wild-type (WT) mice. Values are means ± SEM, n = 6. **P < 0.01, ***P < 0.005; canagliflozin-treated versus non-treated mice. Immunostaining for Agt (D) and immunoflourescent staining of Sglt2 (E) in the kidneys of WT male and female mice with or without 4 weeks of canagliflozin treatment. Magnification x 200. Scale bars = 50 μm. Semi-quantification of Agt (F) and Sglt2 (G) immunostaining in male and female WT mouse kidneys after 4 weeks of treatment with or without canagliflozin. RT-qPCR of Agt (H) and Sglt2 (I) expression in isolated RPTs of WT male and female mice with or without 4 weeks of canagliflozin treatment. Values are means ± SEM, n = 6. NS, not significant; canagliflozin treated versus non-treated mice.