Fig. 5.

Dose response of the effects of IC inhibition on HO and effects of PD1 antibody on CD206+/F480+ macrophage numbers and cytokine expression. a, b The effects of IC antibodies, particularly CD134L and PD-L1, on HO are dose dependent. c Effects of PD1 antibody (10 μg) on the number of CD206+/F480+ cells in tissue. Values are means ± SEM. N = 5. **Differs from other groups at P < 0.01. d Cytokine mRNA expression in Nse-BMP mice with and without PD1 antibody. Values are expressed as fold-change from the WT level. N = 4. *Differs from WT at P < 0.05; **Differs from WT at P < 0.01; ^&Differs from both other groups at P < 0.02; ^$Differs from both other groups at P < 0.05. Statistics were performed with ANOVA with Bonferroni’s post hoc test