Fig. 3.

ND10885 treatment in infected marmosets allows cavity formation. a Lesion pathology at necropsy for marmosets treated with three different drug regimens. HRZE, isoniazid, rifampicin, pyrazinamide, and ethambutol; HS, isoniaizid, and streptomycin (CFU data and PK have been previously published for both control arms; ref. ²⁸). Each number refers to an individual animal and each symbol above it describes the pathology of each individual lesion within that animal, the size of the symbol is according to the size of the lesion, small symbols are 1 mm lesions and the largest symbols are ~10 mm lesions. The inset bar graph summarizes the same data according to the total percentage of lesions in each of the three pathology types. Source data are provided as a Source Data file. b an example of PET/CT images of one animal treated with ND10885 over time, the first image is 37 days after infection with a low-dose aerosol of M. tuberculosis, the second image is day 51 and immediately after that image the animal began receiving ND10885. There are two lesions, one on the right and one on the left that progressively cavitate and expel their contents. c Pathology images of one of these cavities showing on the top left the H&E stained slice and on the right the Masson’s Trichrome stain to illustrate the fibrous cavity wall. In both panels the scale bar is 500 μm. The small black box in the H&E slice is shown at ×100 with a 10-μm scale bar with acid-fast staining showing the presence of multiple individual bacilli (circled)