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. 2019 Oct 31;9:15752. doi: 10.1038/s41598-019-51775-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cytoprotective effects of AdMSCs. (A) Immunohistochemistry revealed the expressions of AQP5 (a marker of salivary epithelial cells) and CD31 (an endothelial cell marker) were lower in the RI + PBS sham group than in the RI + AdMSCs and PBS sham groups. (magnification power: x40, Scale bars = 50 μm) Arrow represents the apical localization of AQP5 (magnification power: x200). (B,C) Quantitative analysis showed the expressions AQP5 and CD31 were greater in the RI + AdMSCs group than in the RI + PBS sham group. Results are presented as means ± SEMs. One-way ANOVA, Tukey’s post hoc multiple comparison test. (*compare to PBS sham; ^#compare to RI + PBS sham, ***p < 0.001, ^###p < 0.001). Abbreviation: AdMSC, adipose-derived mesenchymal stem cells; PBS, phosphate-buffered saline.