Table.

'Voltage drop' at the population level for interventions found to have efficacy in randomized clinical trials: An illustrative example for neoadjuvant chemotherapy for muscle-invasive bladder cancer with methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC).[25]

Dissemination	Concept	Impacted
50% Clinics use MVAC	Adoption	50%
50% Practitioners recommend MVAC	Adoption	25%
50% Patients accept recommendation/attempt MVAC	Reach	12.5%
50% Follow MVAC regimen correctly	Implementation	6.2%
50% Implementing MVAC have substantial benefit	Effectiveness	3.1%
50% Continue to benefit/adhere to MVAC protocol (e.g., go on to radical cystectomy) after 6 months	Maintenance	1.6%

^*Based on the RE-AIM Framework by Glasgow et al.[26]