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The binding mode of tamoxifen (yellow) and GA (red) with human estrogen receptor alpha (PDB code: 3ERT). Tamoxifen is connected to ERα via two H-bond (Arg 394 and Glu 353) and GA is connected to ERα via four H-bond with Arg 394, Leu 346, Glu 353. The hydrogen bonds are shown in yellow
