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. 2019 Oct 25;10:768. doi: 10.3389/fpsyt.2019.00768

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Copyright © 2019 Jager, Kanters, Geers, Buitelaar, Kozicz and Glennon

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Open-field experiment. (A) Typical representations of exploratory patterns of BALB/cJ mice in open field. While the vehicle remains most of the time at the start position, the methylphenidate (MPH)-treated animals explore the whole field, and (B) MPH increased the number of center visits and (C) the distance traveled as well as (D) the velocity. Abbreviations: VEH, vehicle; MPH3, 3 mg/kg i.p. methylphenidate; MPH10, 10 mg/kg i.p. methylphenidate. N = 12 per group, *p < 0.05, ***p < 0.001.