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. 2019 Oct 25;10:768. doi: 10.3389/fpsyt.2019.00768

Figure 3.

Figure 3

Elevated plus maze. (A) Typical representations of exploratory patterns of BALB/cJ mice on the elevated plus maze. While the vehicle remains in the closed arms for most of the time, the methylphenidate (MPH)-treated animals explore the open arms. (B) MPH increased the time spent on the open arms as a ratio of the time spent on both the closed and open arms. (C) The vehicle-treated animals stay in the center of the maze. (D) The MPH-treated animals spent more time in the distal parts of the open arms. Abbreviations: VEH, vehicle; MPH3, 3 mg/kg i.p. methylphenidate; MPH10, 10 mg/kg i.p. methylphenidate. N = 12 per group, *p < 0.05, **p < 0.01.