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. 2019 Oct 25;10:768. doi: 10.3389/fpsyt.2019.00768

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Copyright © 2019 Jager, Kanters, Geers, Buitelaar, Kozicz and Glennon

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Social interaction test. (A) BALB/cJ mice treated with vehicle and 3 mg/kg i.p. methylphenidate (MPH) show a preference for the non-social zone. (B) The dose of 3 mg/kg i.p. MPH increased the preference for the non-social cylinder in comparison to the social cylinder and the vehicle-treated mice. (C) Both the vehicle-treated and 10 mg/kg i.p. MPH-treated mice show a longer interaction time with the social cylinder, while this is not the case for the 3 mg/kg group. Abbreviations: VEH, vehicle; MPH3, 3 mg/kg i.p. MPH; MPH10, 10 mg/kg i.p. MPH. N = 12 per group, ^#p < 0.10; *p < 0.05; ***p < 0.001.