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. 2019 Oct 25;10:768. doi: 10.3389/fpsyt.2019.00768

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Copyright © 2019 Jager, Kanters, Geers, Buitelaar, Kozicz and Glennon

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Resident–intruder test. (A) The attack latency over the five testing days did not significantly differ between the treatment groups. (B) The average attack latency over the last 3 days is significantly higher in the 3 mg/kg methylphenidate (MPH)-treated group. (C) The number of bites increased after administration of 10 mg/kg MPH on the first day. While the number of bites increased over time for the vehicle-treated BALB/cJ mice, the number of bites remained low for the group treated with 3 mg/kg MPH. (D) The group treated with 10 mg/kg MPH had an increased number of attacks on day 1 and on day 5 in comparison to the 3 mg/kg MPH-treated group. (E) Threat behavior significantly reduced in the group treated with 3 mg/kg MPH, while this increased for the vehicle-treated group. VEH, vehicle; MPH3, 3 mg/kg i.p. MPH; MPH10, 10 mg/kg i.p. MPH. N = 12 per group, #p < 0.10; *p < 0.05; **p < 0.01.