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SCD1 deficiency enhances PGC-1α expression through mTORC1 activation. (A) 10–12 weeks old male LOX and LKO mice were fed HCD for 10 days. (B) 10 weeks old male LOX and LKO mice were fed a HCD and treated with rapamycin 2 mg/Kg body weight daily for 10 days. Liver PGC-1a gene expression was analyzed as indicated using real time PCR. Values are mean ± SEM (n = 4–6/group), *P < 0.05 vs LOX counterparts and #P < 0.05 vs vehicle treated LKO by student’s two-tailed t test.
