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. 2019 Apr 17;40(41):3409–3417. doi: 10.1093/eurheartj/ehz203

Figure 2.

Figure 2

Effect of metformin ton left ventricular mass index and left ventricular mass. (A) This graph illustrates the effect of 12 months of metformin or placebo treatment on the left ventricular mass index. Metformin significantly reduced left ventricular mass index after 12 months of therapy compared with placebo (P = 0.033 for modified intention-to-treat and P = 0.005 for per-protocol analysis). (B) This graph illustrates the effect of 12 months of metformin or placebo treatment on the left ventricular mass. Metformin significantly reduced left ventricular mass after 12 months of therapy compared with placebo (P = 0.032 for modified intention-to-treat and P = 0.005 for per-protocol analysis.