Fig. 1.

Simulation of the edge smoothing procedure. From left to right: the original protein-protein interaction network, the adjusted network with dummy nodes (squares) for each protein-protein edge, somatic mutations shown as black nodes, and the result of the network smoothing procedure applied to the adjusted network with dummy nodes. White and black nodes in the third panel show assignment of values 0 and 1 (respectively) to nodes, and the fourth panel shows continuous node values in [0,1], denoting the smoothed score for each protein and protein-protein interaction