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. 2019 Oct 25;13:1127. doi: 10.3389/fnins.2019.01127

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Copyright © 2019 Wang, Li, Zacharek, Landschoot-Ward, Chopp, Chen and Cui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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L-4F treatment decreases RAGE/ED1/HMGB-1, and PAI-1 in the ischemic brain in T2DM mice 4 days after MCAo. (A–D) HMGB-1 immunostaining and quantitative data; (E,F) RAGE/ED1/HMGB-1 WB assay and quantitative data; (G,H) TNFα/PAI-1 WB assay and quantitative data; (I) TNFα/PAI-1 RT-PCR data. Scale bar in (A–C) = 50 μm; ^∗p < 0.05, n = 11/group in (A–D); n = 6/group in (A–I).