Table 13.
Five-year total, annual average totala, and average annual age-adjusted incidence ratesb with 95% confidence intervals for all brain and other central nervous system tumors by major histology grouping, histology, hispanic ethnicityc, and race, CBTRUS Statistical Report: U.S. Cancer Statistics – NPCR and SEER, 2012–2016
| Histology | All Hispanic | White Hispanic | Black Hispanic | All Non-Hispanic | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-year Total | Annual average | Rate | 95% CI | 5-year Total | Annual average | Rate | 95% CI | 5-year Total | Annual average | Rate | 95% CI | 5-year Total | Annual average | Rate | 95% CI | |
| Tumors of Neuroepithelial Tissue | 11,414 | 2,283 | 4.96 | 4.86–5.06 | 10,492 | 2,098 | 5.04 | 4.94–5.15 | 276 | 55 | 2.51 | 2.18–2.87 | 100,866 | 20,173 | 6.85 | 6.81–6.89 |
| Pilocytic Astrocytoma | 826 | 165 | 0.25 | 0.23–0.27 | 744 | 149 | 0.25 | 0.23–0.27 | 25 | 5 | 0.13 | 0.08–0.20 | 4,340 | 868 | 0.38 | 0.37–0.39 |
| Diffuse Astrocytoma | 804 | 161 | 0.33 | 0.31–0.36 | 732 | 146 | 0.33 | 0.31–0.36 | 17 | 3 | 0.13 | 0.07–0.23 | 6,696 | 1,339 | 0.49 | 0.47–0.50 |
| Anaplastic Astrocytoma | 659 | 132 | 0.29 | 0.26–0.31 | 611 | 122 | 0.29 | 0.27–0.32 | 17 | 3 | 0.15 | 0.08–0.25 | 6,356 | 1,271 | 0.44 | 0.43–0.45 |
| Unique Astrocytoma Variants | 189 | 38 | 0.06 | 0.06–0.08 | 175 | 35 | 0.07 | 0.06–0.08 | -- | -- | -- | -- | 972 | 194 | 0.08 | 0.07–0.08 |
| Malignant | 115 | 23 | 0.04 | 0.03–0.05 | 109 | 22 | 0.04 | 0.04–0.05 | -- | -- | -- | -- | 670 | 134 | 0.05 | 0.05–0.06 |
| Non-Malignant | 74 | 15 | 0.02 | 0.02–0.03 | 66 | 13 | 0.02 | 0.02–0.03 | -- | -- | -- | -- | 302 | 60 | 0.03 | 0.02–0.03 |
| Glioblastoma | 4,491 | 898 | 2.41 | 2.33–2.48 | 4,208 | 842 | 2.46 | 2.39–2.54 | 111 | 22 | 1.35 | 1.09–1.65 | 54,673 | 10,935 | 3.31 | 3.29–3.34 |
| Oligodendroglioma | 429 | 86 | 0.17 | 0.15–0.18 | 386 | 77 | 0.17 | 0.15–0.18 | -- | -- | -- | -- | 3,239 | 648 | 0.25 | 0.24–0.26 |
| Anaplastic Oligodendroglioma | 217 | 43 | 0.09 | 0.08–0.11 | 199 | 40 | 0.09 | 0.08–0.11 | -- | -- | -- | -- | 1,591 | 318 | 0.11 | 0.11–0.12 |
| Oligoastrocytic Tumors | 223 | 45 | 0.09 | 0.08–0.10 | 207 | 41 | 0.09 | 0.08–0.11 | -- | -- | -- | -- | 1,880 | 376 | 0.14 | 0.14–0.15 |
| Ependymal Tumors | 950 | 190 | 0.36 | 0.34–0.39 | 858 | 172 | 0.36 | 0.34–0.39 | 18 | 4 | 0.15 | 0.08–0.26 | 5,927 | 1,185 | 0.44 | 0.43–0.45 |
| Malignant | 632 | 126 | 0.23 | 0.21–0.25 | 580 | 116 | 0.24 | 0.22–0.26 | -- | -- | -- | -- | 3,373 | 675 | 0.25 | 0.25–0.26 |
| Non-Malignant | 318 | 64 | 0.13 | 0.12–0.15 | 278 | 56 | 0.13 | 0.11–0.14 | -- | -- | -- | -- | 2,554 | 511 | 0.18 | 0.18–0.19 |
| Glioma Malignant, NOS | 966 | 193 | 0.37 | 0.34–0.40 | 874 | 175 | 0.37 | 0.35–0.40 | 30 | 6 | 0.20 | 0.13–0.31 | 6,785 | 1,357 | 0.52 | 0.50–0.53 |
| Choroid Plexus Tumors | 152 | 30 | 0.05 | 0.04–0.06 | 137 | 27 | 0.05 | 0.04–0.06 | -- | -- | -- | -- | 665 | 133 | 0.05 | 0.05–0.06 |
| Malignant | 23 | 5 | 0.01 | 0.00–0.01 | 20 | 4 | 0.01 | 0.00–0.01 | -- | -- | -- | -- | 108 | 22 | 0.01 | 0.01-0.01 |
| Non-Malignant | 129 | 26 | 0.04 | 0.04–0.05 | 117 | 23 | 0.04 | 0.04–0.05 | -- | -- | -- | -- | 557 | 111 | 0.05 | 0.04–0.05 |
| Other Neuroepithelial Tumors | 21 | 4 | 0.01 | 0.00–0.01 | 18 | 4 | 0.01 | 0.00–0.01 | -- | -- | -- | -- | 88 | 18 | 0.01 | 0.01-0.01 |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | 60 | 12 | 0.00 | 0.00–0.01 |
| Non-Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | 28 | 6 | 0.00 | 0.00-0.00 |
| Neuronal and Mixed Neuronal Glial Tumors | 631 | 126 | 0.22 | 0.20–0.24 | 556 | 111 | 0.21 | 0.19–0.23 | -- | -- | -- | -- | 4,221 | 844 | 0.34 | 0.33–0.35 |
| Malignant | 127 | 25 | 0.05 | 0.04–0.06 | 113 | 23 | 0.05 | 0.04–0.06 | -- | -- | -- | -- | 849 | 170 | 0.06 | 0.05–0.06 |
| Non-Malignant | 504 | 101 | 0.16 | 0.15–0.18 | 443 | 89 | 0.16 | 0.15–0.18 | -- | -- | -- | -- | 3,372 | 674 | 0.28 | 0.27–0.29 |
| Tumors of the Pineal Region | 108 | 22 | 0.04 | 0.03–0.05 | 99 | 20 | 0.04 | 0.03–0.05 | -- | -- | -- | -- | 688 | 138 | 0.05 | 0.05–0.06 |
| Malignant | 71 | 14 | 0.02 | 0.02–0.03 | 65 | 13 | 0.02 | 0.02–0.03 | -- | -- | -- | -- | 374 | 75 | 0.03 | 0.03-0.03 |
| Non-Malignant | 37 | 7 | 0.01 | 0.01–0.02 | 34 | 7 | 0.01 | 0.01–0.02 | -- | -- | -- | -- | 314 | 63 | 0.02 | 0.02–0.03 |
| Embryonal Tumors | 748 | 150 | 0.22 | 0.21–0.24 | 688 | 138 | 0.23 | 0.22–0.25 | -- | -- | -- | -- | 2,745 | 549 | 0.24 | 0.23–0.25 |
| Tumors of Cranial and Spinal Nerves | 3,128 | 626 | 1.41 | 1.36–1.46 | 2,794 | 559 | 1.39 | 1.34–1.44 | 81 | 16 | 0.77 | 0.60–0.98 | 31,925 | 6,385 | 2.11 | 2.09–2.14 |
| Nerve Sheath Tumors | 3,122 | 624 | 1.41 | 1.36–1.46 | 2,788 | 558 | 1.39 | 1.33–1.44 | 81 | 16 | 0.77 | 0.60–0.98 | 31,895 | 6,379 | 2.11 | 2.09–2.13 |
| Malignant | 37 | 7 | 0.02 | 0.01–0.02 | 33 | 7 | 0.02 | 0.01–0.02 | -- | -- | -- | -- | 194 | 39 | 0.01 | 0.01–0.02 |
| Non-Malignant | 3,085 | 617 | 1.39 | 1.34–1.44 | 2,755 | 551 | 1.37 | 1.32–1.42 | -- | -- | -- | -- | 31,701 | 6,340 | 2.10 | 2.07–2.12 |
| Other Tumors of Cranial and Spinal Nerves | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | 30 | 6 | 0.00 | 0.00-0.00 |
| Tumors of Meninges | 15,279 | 3,056 | 8.36 | 8.22–8.50 | 13,917 | 2,783 | 8.32 | 8.18–8.47 | 438 | 88 | 5.56 | 5.01–6.15 | 142,031 | 28,406 | 8.93 | 8.89–8.98 |
| Meningioma | 14,679 | 2,936 | 8.11 | 7.98–8.25 | 13,359 | 2,672 | 8.07 | 7.93–8.22 | 428 | 86 | 5.48 | 4.93–6.07 | 138,077 | 27,615 | 8.65 | 8.61–8.70 |
| Malignant | 181 | 36 | 0.09 | 0.08–0.11 | 170 | 34 | 0.10 | 0.08–0.11 | -- | -- | -- | -- | 1,593 | 319 | 0.10 | 0.09–0.10 |
| Non-Malignant | 14,498 | 2,900 | 8.02 | 7.88–8.16 | 13,189 | 2,638 | 7.97 | 7.83–8.12 | -- | -- | -- | -- | 136,484 | 27,297 | 8.55 | 8.51–8.60 |
| Mesenchymal Tumors | 206 | 41 | 0.09 | 0.07–0.10 | 193 | 39 | 0.09 | 0.08–0.10 | -- | -- | -- | -- | 1,227 | 245 | 0.09 | 0.08–0.09 |
| Primary Melanocytic Lesions | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | 99 | 20 | 0.01 | 0.01-0.01 |
| Other Neoplasms Related to the Meninges | 384 | 77 | 0.16 | 0.14–0.17 | 356 | 71 | 0.16 | 0.14–0.18 | -- | -- | -- | -- | 2,628 | 526 | 0.19 | 0.18–0.19 |
| Lymphoma and Hematopoietic Neoplasms | 920 | 184 | 0.49 | 0.46–0.52 | 864 | 173 | 0.51 | 0.47–0.54 | 16 | 3 | 0.14 | 0.08–0.23 | 6,994 | 1,399 | 0.44 | 0.43–0.45 |
| Lymphoma | 879 | 176 | 0.47 | 0.44–0.51 | 828 | 166 | 0.49 | 0.46–0.53 | -- | -- | -- | -- | 6,801 | 1,360 | 0.42 | 0.41–0.43 |
| Other Hematopoietic Neoplasms | 41 | 8 | 0.02 | 0.01–0.02 | 36 | 7 | 0.02 | 0.01–0.02 | -- | -- | -- | -- | 193 | 39 | 0.01 | 0.01–0.02 |
| Germ Cell Tumors and Cysts | 334 | 67 | 0.10 | 0.09–0.12 | 300 | 60 | 0.10 | 0.09–0.12 | -- | -- | -- | -- | 1,209 | 242 | 0.10 | 0.10–0.11 |
| Germ cell tumors, cysts, and heterotopias | 334 | 67 | 0.10 | 0.09–0.12 | 300 | 60 | 0.10 | 0.09–0.12 | -- | -- | -- | -- | 1,209 | 242 | 0.10 | 0.10–0.11 |
| Malignant | 235 | 47 | 0.07 | 0.06–0.08 | 215 | 43 | 0.07 | 0.06–0.08 | -- | -- | -- | -- | 802 | 160 | 0.07 | 0.06–0.07 |
| Non-Malignant | 99 | 20 | 0.03 | 0.03–0.04 | 85 | 17 | 0.03 | 0.03–0.04 | -- | -- | -- | -- | 407 | 81 | 0.03 | 0.03–0.04 |
| Tumors of Sellar Region | 11,235 | 2,247 | 4.77 | 4.68–4.86 | 10,015 | 2,003 | 4.71 | 4.61–4.80 | 370 | 74 | 3.32 | 2.95–3.71 | 59,849 | 11,970 | 4.20 | 4.17–4.24 |
| Tumors of the Pituitary | 10,775 | 2,155 | 4.60 | 4.51–4.69 | 9,593 | 1,919 | 4.53 | 4.44–4.63 | 357 | 71 | 3.24 | 2.88–3.63 | 57,245 | 11,449 | 4.01 | 3.98–4.04 |
| Malignant | 28 | 6 | 0.01 | 0.01–0.02 | 22 | 4 | 0.01 | 0.01–0.02 | -- | -- | -- | -- | 129 | 26 | 0.01 | 0.01-0.01 |
| Non-Malignant | 10,747 | 2,149 | 4.58 | 4.49–4.68 | 9,571 | 1,914 | 4.52 | 4.42–4.62 | 356 | 71 | 3.23 | 2.87–3.62 | 57,116 | 11,423 | 4.00 | 3.97–4.03 |
| Craniopharyngioma | 460 | 92 | 0.17 | 0.16–0.19 | 422 | 84 | 0.18 | 0.16–0.20 | -- | -- | -- | -- | 2,604 | 521 | 0.19 | 0.19–0.20 |
| Unclassified Tumors | 2,379 | 476 | 1.19 | 1.13–1.24 | 2,172 | 434 | 1.19 | 1.14–1.25 | 67 | 13 | 0.70 | 0.52–0.92 | 18,177 | 3,635 | 1.21 | 1.19–1.22 |
| Hemangioma | 807 | 161 | 0.34 | 0.32–0.37 | 736 | 147 | 0.35 | 0.32–0.38 | 22 | 4 | 0.19 | 0.11–0.30 | 5,175 | 1,035 | 0.37 | 0.36–0.38 |
| Neoplasm Unspecified | 1,548 | 310 | 0.83 | 0.78–0.87 | 1,414 | 283 | 0.83 | 0.79–0.88 | 45 | 9 | 0.51 | 0.35–0.71 | 12,870 | 2,574 | 0.83 | 0.81–0.84 |
| Malignant | 600 | 120 | 0.36 | 0.33–0.39 | 552 | 110 | 0.36 | 0.33–0.39 | -- | -- | -- | -- | 6,034 | 1,207 | 0.37 | 0.36–0.38 |
| Non-Malignant | 948 | 190 | 0.47 | 0.44–0.50 | 862 | 172 | 0.47 | 0.44–0.51 | -- | -- | -- | -- | 6,836 | 1,367 | 0.46 | 0.45–0.47 |
| All Other | 24 | 5 | 0.01 | 0.01–0.02 | 22 | 4 | 0.01 | 0.01–0.02 | -- | -- | -- | -- | 132 | 26 | 0.01 | 0.01-0.01 |
| TOTAL d | 44,689 | 8,938 | 21.28 | 21.07–21.49 | 40,554 | 8,111 | 21.27 | 21.05–21.49 | 1,257 | 251 | 13.04 | 12.25–13.87 | 361,051 | 72,210 | 23.84 | 23.76–23.92 |
| Malignant | 12,451 | 2,490 | 5.66 | 5.56–5.77 | 11,507 | 2,301 | 5.78 | 5.67–5.90 | 287 | 57 | 2.64 | 2.30–3.01 | 110,118 | 22,024 | 7.33 | 7.29–7.38 |
| Non-Malignant | 32,238 | 6,448 | 15.61 | 15.43–15.80 | 29,047 | 5,809 | 15.49 | 15.30–15.68 | 970 | 194 | 10.40 | 9.69–11.15 | 250,933 | 50,187 | 16.51 | 16.44–16.58 |
a. Annual average cases are calculated by dividing the five-year total by five.
b. Rates are per 100,000 and are age-adjusted to the 2000 US standard population.
c. Hispanic ethnicity is not mutually exclusive of race; Classified using the North American Association of Central Cancer Registries Hispanic Identification Algorithm, version 2 (NHIA v2).
d. Refers to all brain tumors including histologies not presented in this table.
- Counts and rates are not presented when fewer than 16 cases were reported for the specific category, or where the inclusion of the count and rate would allow for back-calculation of suppressed values. The suppressed cases are included in the counts and rates for Totals.
Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; CI, Confidence Interval; NOS, Not otherwise specified