Table 7.
Average annual age-specific incidence ratesa with 95% confidence intervals for all brain and other central nervous system tumors by major histology grouping, histology, and age at diagnosis, CBTRUS Statistical Report: U.S. Cancer Statistics – NPCR and SEER, 2012–2016
| Histology | Age At Diagnosis | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 20–34 Years | 35–44 Years | 45–54 Years | 55–64 Years | 65–74 Years | 75–84 Years | 85+ Years | ||||||||
| Rate | 95% CI | Rate | 95% CI | Rate | 95% CI | Rate | 95% CI | Rate | 95% CI | Rate | 95% CI | Rate | 95% CI | |
| Tumors of Neuroepithelial Tissue | 3.34 | 3.28–3.40 | 4.44 | 4.35–4.54 | 6.67 | 6.56–6.78 | 11.32 | 11.17–11.47 | 16.88 | 16.65–17.10 | 19.34 | 19.01–19.67 | 12.21 | 11.82–12.60 |
| Pilocytic Astrocytoma | 0.21 | 0.20–0.23 | 0.12 | 0.11–0.14 | 0.09 | 0.08–0.11 | 0.07 | 0.06–0.08 | 0.06 | 0.05–0.08 | 0.07 | 0.05–0.09 | -- | -- |
| Diffuse Astrocytoma | 0.47 | 0.44–0.49 | 0.49 | 0.46–0.52 | 0.47 | 0.44–0.50 | 0.59 | 0.56–0.63 | 0.80 | 0.75–0.85 | 0.89 | 0.82–0.96 | 0.49 | 0.42–0.58 |
| Anaplastic Astrocytoma | 0.37 | 0.35–0.39 | 0.47 | 0.44–0.50 | 0.50 | 0.47–0.53 | 0.67 | 0.64–0.71 | 0.93 | 0.88–0.99 | 0.94 | 0.87–1.02 | 0.42 | 0.35–0.50 |
| Unique Astrocytoma Variants | 0.07 | 0.06–0.08 | 0.04 | 0.04–0.06 | 0.03 | 0.03–0.04 | 0.04 | 0.03–0.05 | 0.07 | 0.05–0.08 | 0.08 | 0.06–0.11 | 0.07 | 0.05–0.11 |
| Malignant | 0.05 | 0.04–0.06 | 0.04 | 0.03–0.05 | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 0.02 | 0.01–0.02 | 0.01 | 0.01-0.01 | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Glioblastoma | 0.46 | 0.44–0.49 | 1.24 | 1.19–1.29 | 3.57 | 3.49–3.65 | 8.07 | 7.94–8.19 | 12.98 | 12.78–13.17 | 15.29 | 14.99–15.58 | 9.06 | 8.73–9.41 |
| Oligodendroglioma | 0.28 | 0.26–0.30 | 0.42 | 0.39–0.44 | 0.37 | 0.34–0.40 | 0.28 | 0.25–0.30 | 0.19 | 0.17–0.22 | 0.13 | 0.11–0.16 | 0.08 | 0.05–0.12 |
| Anaplastic Oligodendroglioma | 0.09 | 0.08–0.10 | 0.18 | 0.16–0.20 | 0.21 | 0.19–0.23 | 0.19 | 0.17–0.21 | 0.16 | 0.14–0.19 | 0.12 | 0.09–0.15 | -- | -- |
| Oligoastrocytic Tumors | 0.19 | 0.18–0.21 | 0.24 | 0.21–0.26 | 0.17 | 0.15–0.19 | 0.15 | 0.13–0.17 | 0.14 | 0.12–0.16 | 0.09 | 0.06–0.11 | -- | -- |
| Ependymal Tumors | 0.36 | 0.34–0.38 | 0.52 | 0.49–0.56 | 0.57 | 0.54–0.60 | 0.55 | 0.52–0.59 | 0.60 | 0.56–0.64 | 0.42 | 0.37–0.47 | 0.13 | 0.10–0.18 |
| Malignant | 0.19 | 0.17–0.20 | 0.28 | 0.26–0.30 | 0.29 | 0.27–0.31 | 0.30 | 0.27–0.32 | 0.32 | 0.29–0.35 | 0.25 | 0.22–0.29 | 0.06 | 0.04–0.10 |
| Non-Malignant | 0.17 | 0.16–0.19 | 0.25 | 0.22–0.27 | 0.28 | 0.26–0.31 | 0.25 | 0.23–0.28 | 0.28 | 0.25–0.31 | 0.16 | 0.14–0.20 | 0.07 | 0.04–0.11 |
| Glioma Malignant, NOS | 0.27 | 0.26–0.29 | 0.26 | 0.24–0.29 | 0.31 | 0.29–0.34 | 0.36 | 0.34–0.39 | 0.59 | 0.55–0.64 | 1.04 | 0.96–1.12 | 1.74 | 1.60–1.90 |
| Choroid Plexus Tumors | 0.04 | 0.03–0.04 | 0.04 | 0.03–0.05 | 0.03 | 0.02–0.04 | 0.03 | 0.02–0.04 | 0.04 | 0.03–0.05 | 0.03 | 0.02–0.05 | -- | -- |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other Neuroepithelial Tumors | 0.01 | 0.00–0.01 | 0.01 | 0.01-0.01 | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Neuronal and Mixed Neuronal Glial Tumors | 0.31 | 0.29–0.33 | 0.26 | 0.24–0.28 | 0.24 | 0.22–0.26 | 0.22 | 0.20–0.24 | 0.23 | 0.20–0.25 | 0.18 | 0.15–0.21 | 0.08 | 0.06–0.12 |
| Malignant | 0.03 | 0.03–0.04 | 0.07 | 0.05–0.08 | 0.08 | 0.07–0.09 | 0.10 | 0.08–0.11 | 0.12 | 0.10–0.14 | 0.11 | 0.08–0.13 | -- | -- |
| Non-Malignant | 0.28 | 0.26–0.30 | 0.19 | 0.18–0.21 | 0.16 | 0.14–0.18 | 0.12 | 0.10–0.13 | 0.10 | 0.09–0.12 | 0.07 | 0.05–0.09 | -- | -- |
| Tumors of the Pineal Region | 0.05 | 0.05–0.06 | 0.06 | 0.05–0.07 | 0.05 | 0.04–0.06 | 0.04 | 0.03–0.05 | 0.05 | 0.04–0.06 | 0.03 | 0.02–0.05 | -- | -- |
| Malignant | 0.03 | 0.02–0.03 | 0.02 | 0.02–0.03 | 0.03 | 0.02–0.03 | 0.02 | 0.01–0.03 | 0.02 | 0.01–0.03 | -- | -- | -- | -- |
| Non-Malignant | 0.03 | 0.02–0.03 | 0.03 | 0.03–0.04 | 0.03 | 0.02–0.03 | 0.02 | 0.02–0.03 | 0.03 | 0.02–0.04 | -- | -- | -- | -- |
| Embryonal Tumors | 0.15 | 0.14–0.17 | 0.09 | 0.08–0.11 | 0.05 | 0.04–0.06 | 0.05 | 0.04–0.06 | 0.04 | 0.03–0.05 | 0.04 | 0.02–0.05 | -- | -- |
| Tumors of Cranial and Spinal Nerves | 0.94 | 0.90–0.97 | 2.11 | 2.05–2.17 | 3.27 | 3.20–3.35 | 4.50 | 4.40–4.59 | 5.23 | 5.11–5.36 | 4.01 | 3.86–4.16 | 1.75 | 1.60–1.90 |
| Nerve Sheath Tumors | 0.94 | 0.90–0.97 | 2.11 | 2.04–2.17 | 3.27 | 3.19–3.35 | 4.49 | 4.40–4.59 | 5.23 | 5.10–5.35 | 4.00 | 3.85–4.16 | 1.75 | 1.60–1.90 |
| Malignant | 0.01 | 0.01-0.01 | 0.02 | 0.01–0.02 | 0.02 | 0.01–0.03 | 0.02 | 0.01–0.03 | 0.03 | 0.02–0.05 | 0.03 | 0.02–0.05 | -- | -- |
| Non-Malignant | 0.93 | 0.89–0.96 | 2.09 | 2.03–2.15 | 3.25 | 3.17–3.33 | 4.47 | 4.38–4.57 | 5.19 | 5.07–5.32 | 3.97 | 3.83–4.13 | -- | -- |
| Other Tumors of Cranial and Spinal Nerves | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Tumors of Meninges | 1.69 | 1.64–1.73 | 5.71 | 5.61–5.82 | 10.60 | 10.47–10.74 | 16.52 | 16.34–16.70 | 28.62 | 28.32–28.91 | 42.23 | 41.74–42.72 | 53.52 | 52.70–54.34 |
| Meningioma | 1.44 | 1.40–1.48 | 5.39 | 5.29–5.50 | 10.22 | 10.09–10.36 | 16.09 | 15.92–16.27 | 28.16 | 27.87–28.46 | 41.80 | 41.31–42.28 | 53.37 | 52.56–54.20 |
| Malignant | 0.02 | 0.01–0.02 | 0.05 | 0.04–0.06 | 0.11 | 0.09–0.12 | 0.20 | 0.18–0.22 | 0.35 | 0.32–0.38 | 0.45 | 0.40–0.50 | 0.57 | 0.49–0.66 |
| Non-Malignant | 1.42 | 1.38–1.46 | 5.34 | 5.24–5.45 | 10.12 | 9.98–10.25 | 15.89 | 15.72–16.07 | 27.81 | 27.52–28.10 | 41.35 | 40.87–41.83 | 52.81 | 52.00–53.62 |
| Mesenchymal Tumors | -- | -- | -- | -- | 0.12 | 0.11–0.14 | 0.12 | 0.11–0.14 | -- | -- | -- | -- | -- | -- |
| Primary Melanocytic Lesions | -- | -- | -- | -- | 0.01 | 0.00–0.01 | 0.02 | 0.01–0.02 | -- | -- | -- | -- | -- | -- |
| Other Neoplasms Related to the Meninges | 0.18 | 0.17–0.20 | 0.23 | 0.21–0.26 | 0.25 | 0.23–0.27 | 0.29 | 0.27–0.31 | 0.30 | 0.27–0.33 | 0.27 | 0.23–0.31 | 0.08 | 0.05–0.12 |
| Lymphomas and Hematopoietic Neoplasms | 0.10 | 0.09–0.11 | 0.23 | 0.21–0.25 | 0.40 | 0.38–0.43 | 0.87 | 0.83–0.91 | 1.81 | 1.73–1.88 | 2.41 | 2.30–2.53 | 1.18 | 1.06–1.31 |
| Lymphoma | 0.09 | 0.08–0.10 | 0.21 | 0.19–0.23 | 0.39 | 0.36–0.42 | 0.85 | 0.81–0.89 | 1.78 | 1.71–1.85 | 2.39 | 2.28–2.51 | 1.16 | 1.05–1.29 |
| Other hematopoietic Neoplasms | 0.01 | 0.01-0.01 | 0.01 | 0.01–0.02 | 0.01 | 0.01–0.02 | 0.01 | 0.01–0.02 | 0.03 | 0.02–0.04 | -- | -- | -- | -- |
| Germ Cell Tumors and Cysts | 0.11 | 0.10–0.12 | 0.04 | 0.03–0.05 | 0.03 | 0.02–0.04 | 0.02 | 0.02–0.03 | 0.02 | 0.02–0.03 | -- | -- | -- | -- |
| Germ cell tumors, cysts, and heterotopias | 0.11 | 0.10–0.12 | 0.04 | 0.03–0.05 | 0.03 | 0.02–0.04 | 0.02 | 0.02–0.03 | 0.02 | 0.02–0.03 | -- | -- | -- | -- |
| Malignant | 0.08 | 0.07–0.09 | 0.01 | 0.01-0.01 | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 0.03 | 0.02–0.03 | 0.03 | 0.02–0.04 | 0.03 | 0.02–0.03 | 0.02 | 0.01–0.03 | 0.02 | 0.02–0.03 | -- | -- | -- | -- |
| Tumors of Sellar Region | 3.96 | 3.89–4.03 | 5.45 | 5.35–5.55 | 5.56 | 5.46–5.66 | 6.39 | 6.28–6.51 | 8.22 | 8.06–8.38 | 8.41 | 8.19–8.63 | 5.03 | 4.78–5.29 |
| Tumors of the Pituitary | 3.84 | 3.77–3.91 | 5.28 | 5.18–5.38 | 5.34 | 5.24–5.44 | 6.15 | 6.04–6.26 | 7.95 | 7.80–8.11 | 8.18 | 7.97–8.40 | 4.95 | 4.70–5.21 |
| Malignant | -- | -- | 0.01 | 0.01–0.02 | 0.01 | 0.01–0.02 | 0.02 | 0.01–0.03 | 0.02 | 0.01–0.03 | -- | -- | -- | -- |
| Non-Malignant | -- | -- | 5.27 | 5.17–5.37 | 5.33 | 5.23–5.43 | 6.13 | 6.02–6.24 | 7.93 | 7.78–8.09 | -- | -- | -- | -- |
| Craniopharyngioma | 0.12 | 0.11–0.13 | 0.17 | 0.15–0.18 | 0.22 | 0.20–0.24 | 0.24 | 0.22–0.26 | 0.27 | 0.24–0.30 | 0.22 | 0.19–0.26 | 0.08 | 0.05–0.12 |
| Unclassified Tumors | 0.59 | 0.57–0.62 | 0.86 | 0.82–0.90 | 1.10 | 1.05–1.14 | 1.51 | 1.45–1.56 | 2.48 | 2.39–2.57 | 4.88 | 4.72–5.05 | 10.79 | 10.42–11.16 |
| Hemangioma | 0.30 | 0.28–0.32 | 0.42 | 0.39–0.45 | 0.47 | 0.45–0.50 | 0.53 | 0.50–0.56 | 0.65 | 0.60–0.69 | 0.65 | 0.59–0.72 | 0.54 | 0.46–0.63 |
| Neoplasm Unspecified | 0.30 | 0.28–0.31 | 0.43 | 0.40–0.46 | 0.62 | 0.59–0.65 | 0.97 | 0.93–1.02 | 1.80 | 1.73–1.88 | 4.19 | 4.04–4.35 | 10.18 | 9.83–10.55 |
| Malignant | 0.07 | 0.06–0.07 | 0.11 | 0.10–0.13 | 0.21 | 0.19–0.23 | 0.43 | 0.41–0.46 | 0.88 | 0.83–0.94 | 2.37 | 2.26–2.49 | 5.99 | 5.72–6.27 |
| Non-Malignant | 0.23 | 0.21–0.25 | 0.32 | 0.30–0.35 | 0.41 | 0.38–0.44 | 0.54 | 0.51–0.57 | 0.92 | 0.86–0.97 | 1.82 | 1.72–1.93 | 4.19 | 3.97–4.43 |
| All Other | -- | -- | -- | -- | -- | -- | -- | -- | 0.03 | 0.02–0.04 | 0.04 | 0.02–0.05 | 0.07 | 0.04–0.10 |
| TOTAL b | 10.72 | 10.61–10.84 | 18.83 | 18.65–19.02 | 27.63 | 27.41–27.86 | 41.13 | 40.85–41.41 | 63.25 | 62.82–63.69 | 81.29 | 80.62–81.97 | 84.48 | 83.46–85.52 |
| Malignant | 3.12 | 3.06–3.18 | 4.39 | 4.30–4.48 | 6.98 | 6.87–7.09 | 12.51 | 12.36–12.67 | 19.61 | 19.36–19.85 | 24.43 | 24.06–24.80 | 19.89 | 19.39–20.39 |
| Non-Malignant | 7.61 | 7.51–7.70 | 14.44 | 14.28–14.61 | 20.65 | 20.46–20.85 | 28.62 | 28.38–28.85 | 43.65 | 43.29–44.01 | 56.87 | 56.30–57.43 | 64.59 | 63.70–65.50 |
a. Rates are per 100,000 and age-adjusted to the 2000 US standard population.
b. Refers to all brain tumors including histologies not presented in this table.
-- Counts and rates are not presented when fewer than 16 cases were reported for the specific category, or where the inclusion of the count and rate would allow for back-calculation of suppressed values. The suppressed cases are included in the counts and rates for Totals.
Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; CI, Confidence Interval; NOS, Not otherwise specified