Table 1.

Proportions of internal deletion in the pol gene (Δpol) by partial and full-length pol PCR (pol) in 20 HIV-1 infected individuals treated with Korean Red Ginseng

Patient	Sex/age	Mode of transmission	Total amount of KRG(g)	Duration of KRG treatment	Monthly KRG (g)	AD	gΔnef	No. of PBMC samples	No. of PBMCs with defects	No. of PCR amplicons	No. of Δpol and other defects
87-05	M9	Blood	21258	254	129	22.3	12.1	11	3	26	8
89-14	M29	Homo	5760	51	132	32.4	30.4	8	2	23	3
89-17	M21	Homo	5076	152	33	17.1	17.5	4	2	21	5 + 1*
90-05	M23	Homo	25602	198	130	7.2	15.8	9	0	30	0
90-18	M28	Homo	13182	147	93	45.0	15.6	7	1	18	1
90-50	M20	Homo	18916	171	111	29.4	18.0	3	1	11	4 + 1(ins)
91-20	M30	Homo	14336	188	74	42	15.5	6	1	17	1 + 1*
91-22	M8	Trans	9060	106	98	8.2	8.1	10	3	83	4
92-13	M19	Blood	13470	169	81	12.9	13.5	4	1 + 1(ins)	11	2 + 1(ins)
92-16	M35	Blood	21078	196	107	22.5	17.2	7	1	20	3
92-48	M47	Homo	8300	72	146	60.8	45.4	10	5	52	9
93-04	M30	Homo	9660	160	60	13.3	4.2	6	1(ins)+*	27	0 + 2*,a (ins)
93-60	M26	Hetero	10710	110	93	26	33.3	4	1 + 1*	19	1 + 2*,b
95-87	M32	Homo	4980	40	109	8.5	6.9	8	2	43	5
96-51	M28	Homo	14587	155	88	34.6	11.7	9	2	36	2
97-116	F23	Hetero	9210	162	57	18.1	1.2	13	3	68	3
01-99	F22	Hetero	9738	146	67	11.8	7.0	11	2	62	8
01-179	M37	Homo	8130	82	150	58.8	13.0	11	8	47	17
03-493	M44	Homo	22980	132	174	8.4	11.2 + 100c	19	5 + 1(ins)	64	8 + 1(ins)
04-397	M38	Homo	3120	34	92	79	9.5	4	0	26	0
Total			12,519 ± 6,470	116 ± 58	94 ± 31	27.9 ± 20	15.5 ± 10	164	48	704	84 + 6*+4(ins)

Patients 01-99, 93-60, and 97-116 were infected from their husband 87-05, 89-17, and 90-50, respectively

AD, annual decrease of CD4+ T cells before highly active antiretroviral therapy; blood, blood product; Hetero, heterosexual contact; Homo, homosexual contact; ins, insertion; KRG, Korean Red Ginseng; PBMC, peripheral blood mononuclear cells; trans, transfusion

^aStop codon (*) was detected in an amplicon with the insertion of a nucleotide in patient 93-04 (seq 16337); therefore, total number of amplicons containing defective gene is 93 (13.2%).

^bStop codon was detected in an amplicon with internal deletion in patient 93-60 (MH054715).

^cThere was a deletion of 2-bp just following the end of nef gene in all amplicons.