Fig. 7.

KIR2DL5 modulates NK cell effector function upon interaction with PVR on the cell surface. A, Recognition of PVR on the tumor cell by the activating receptor CD226 on the NK cell results in cell activation and killing. B, NK cell-expressed KIR2DL5 binds to PVR, even in the presence of CD226 co-expressed on the tumor cell, delivering an inhibitory signal that reduces NK-mediated cytolysis of the tumor cell. C, Antibody blockade of KIR2DL5 restores cytotoxic functions and killing of the tumor cell.