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Circulating cell-free BRAFV600E kinetics according to time on vemurafenib and Langerhans cell histiocytosis risk organ extent (18 positive for risk organ involvement [black lines, blue diamonds]; four negative for risk organ involvement [red lines and squares]). The BRAFV600E allele load (expressed as the percentage of mutant alleles relative to the total number of alleles) is shown for each patient before vemurafenib onset (day 0), at weeks 6 to 8, and during months 3 to 6 and 9 to 12.
