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Two-dimensional pose of compounds A1 to A5 and Ibuprofen inside the binding pocket of mouse COX-2 as crystallized by [13]. Ligand-receptor interactions as highlighted by Maestro (Shrodinger, LLC). Ligands are represented in stick, and amino acids within the binding pocket are labeled. An arrow represents the H-bonds between an amino acid and ligand groups. A line shows a potential salt bridge between two charged groups
