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. 2019 Oct 31;23:16. doi: 10.1186/s40824-019-0164-z

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — a Fluorescence microscopic images of histological section of rat skin at 4, 6, 8 and 12 h after topical application of Rho B encapsulated HA-PLGA NPs. Scale bar indicates 100 μm. b Quantitative analysis of fluorescence intensity at each skin layer: stratum corneum (●), epidermis (■), dermis and follicle cells (▲) and only follicle cells (♦). (mean ± SD, n = 5, ***p < 0.001, t-test)