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. 2019 Sep 25;3(11):1520–1543. doi: 10.1002/hep4.1429

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© 2019 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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LAPTM4B depletion induces LMP. (A) Merged immunofluorescence images show lysosomal enzyme (anti‐cathepsin D, red) and lysosomes (anti‐LAMP1, green) according to LAPTM4B status in SULF2‐positive Huh7 cells and SULF2‐transfected Hep3B cells. (B) Merged immunofluorescence images show galectin‐3 (anti‐galectin‐3, red) and lysosomes (anti‐LAMP1, green) according to LAPTM4B status in SULF2‐positive Huh7 cells and SULF2‐transfected Hep3B cells. The cells showing diffuse cytosolic staining of cathepsin D or punctate staining of galectin‐3 were counted by examining a total of 50 cells in 10 random fields (5 cells/field) and presented as a bar graph (mean ± SEM). Abbreviations: CTSD, cathepsin D; LAMP1, lysosome‐associated membrane protein 1; LAPTM4B, lysosome‐associated protein transmembrane 4 beta; LMP, lysosomal membrane permeabilization; SEM, standard error of the mean; SULF2, sulfatase 2.