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. 2019 Sep 25;3(11):1520–1543. doi: 10.1002/hep4.1429

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© 2019 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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LAPTM4B and SULF2 depletion inhibits proliferation and colony formation in HCC cells. MTT assay shows decreased viability after 48 hours (A) and cell transformation assay shows decreased colony formation after 7 days (B) in SULF2‐transfected Hep3B cells treated with scrambled siRNA, LAPTM4B siRNA, SULF2 siRNA, and combined LAPTM4B and SULF2 siRNA. Values for cell viability (percentage of control) and colony formation (absorbance at 570 nm) are presented as a bar graph (mean ± SEM). Abbreviations: LAPTM4B, lysosome‐associated protein transmembrane 4 beta; MTT, 3‐(4,5‐demerthylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide; SEM, standard error of the mean; siRNA; small interfering RNA; SULF2, sulfatase 2.