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. 2019 Sep 24;3(11):1544–1555. doi: 10.1002/hep4.1426

Figure 5.

Figure 5

Expression profile of fibrotic and inflammatory genes in WT and Pygl −/− mice. Quantification of hepatic mRNA for fibrogenic genes (Ctgf, Tgf‐β), inflammatory genes (Il‐6, Tnf‐a), extracellular matrix (Col1a1, Col1a2, Col4a2, Fn 1), and chemokines (Mcp‐1, Ccl5/Rantes, Cxcl1/KC, Mip‐2α/Cxcl2) in (A) young WT (n = 9) and Pygl −/− (n = 24) mice and (B) old WT (n = 16) and Pygl −/− (n = 13) mice. Data represent the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001. Abbreviations: Fn1, fibronectin; Il‐6, interleukin‐6; KC, C‐X‐C chemokine ligand 1; Mip‐2α, macrophage inflammatory protein 2α.