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. 2019 Nov 1;18:151. doi: 10.1186/s12943-019-1072-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — circ-AKT3 inhibits the metastasis of ccRCC in vivo. a-b Bioluminescence imaging of mice 8 weeks after the orthotopically implanted with OSRC-2-Luciferase-circ-AKT3 and OSRC-2-Luciferase-vector (n = 10 per group). Top panel: representative images. Bottom panel: images of metastatic foci of liver, lung, spleen and the metastatic kidney (Kidney(M)) on the other side. c Statistical analysis of mice with liver metastasis in each group. d Total metastatic foci of each mouse counted after dissection. e qRT-PCR analysis of circ-AKT3 and E-cadherin expression in ccRCC metastatic nodules. f-g Immunohistochemistry (IHC) detection of E-cadherin in tumor of mice. Scale bars: 100 μm. Three independent experiments were conducted. **P < 0.01; ***P < 0.001