Table 2.

Effect of fibrin γ/γ’ on secretion of uPA and PAI 1 by HMEC-1. Results are expressed as mean ± standard error (SE). Experiments were performed each time in triplicate in three independent experiments

	uPA		PAI 1
	SN	CL	SN	CL
Basal	0.56 ± 0.09	0.40 ± 0.01	2569 ± 344	1055 ± 85
3% γ/γ’	0.39 ± 0.13	1.73 ± 0.11**ξ	3398 ± 436	770 ± 74
30% γ/γ’	1.06 ± 0.04*	3.21 ± 0.03**	5976 ± 918*	1845 ± 201*
Thrombin	1.04 ± 0.09*	2.42 ± 0.48**	6464 ± 455*	1422 ± 229*

SN: supernatant; CL: cell lysate (1000 cells/μL). uPA and PAI 1 concentrations are in ng/mL

*p < 0.05 when compared to the basal condition and 3% fibrin γ/γ’

**p < 0.05 when compared to the basal condition

^ξp < 0.05 when compared to 30% fibrin γ/γ’