Table 1.

Genomic analysis of the patient's primary angiosarcoma

Gene	Chromosome	Genomic location	HGVS DNA reference	HGVS protein reference	Variant type	Predicted effect	dbSNP/dbVar ID	Genotype
POLE	12	g.133249847G > A	c.1376C > T	p.S459F	Sub	Missense		Heterozygous
TP53	17	g.7578395 G > A	c.535C > T	p.H179Y	Sub	Missense	rs587780070	Heterozygous
CDKN2A	9	g. 21694602–23444942			Homozygous deletion	Whole gene deletion		Homozygous