Table 2.
Quantitative ultrasound: Optimal cutoffs obtained using liver biopsy as the reference standard
| Technique | S0 vs S1–S3 | S0–S1 vs S2–S3 | S0–S2 vs S3 |
| CAP[24,25], dB/m (viral hepatitis) | 219-222 | 233-296 | 290 |
| Sensitivity: 76-91% | Sensitivity: 60-87% | Sensitivity: 78% | |
| Specificity: 52-71% | Specificity: 74-91% | Specificity: 93% | |
| CAP[26-28], dB/m (mixed etiologies) | 255-266 | 283-311 | 293-318 |
| Sensitivity: 65-75% | Sensitivity: 57-86% | Sensitivity: 83-88% | |
| Specificity: 82-87% | Specificity: 85-94% | Specificity: 81-91% | |
| CAP[29], dB/m1 (mixed etiologies) | 248 | 268 | 280 |
| Sensitivity: 69% | Sensitivity: 77% | Sensitivity: 88% | |
| Specificity: 82% | Specificity: 81% | Specificity: 78% | |
| CAP[32], dB/m (NAFLD) | 302 | 331 | 337 |
| Sensitivity: 80% | Sensitivity: 70% | Sensitivity: 72% | |
| Specificity: 83% | Specificity: 76% | Specificity: 63% | |
| ATI[41], dB/cm/MHz (mixed etiologies) | 0.63 | 0.70 | 0.74 |
| Sensitivity: 74% | Sensitivity: 86% | Sensitivity: 100% | |
| Specificity: 77% | Specificity: 81% | Specificity: 82% | |
| UGAP[42], dB/cm/MHz (mixed etiologies) | 0.53 | 0.60 | 0.65 |
| Sensitivity: 81% | Sensitivity: 86% | Sensitivity: 84% | |
| Specificity: 87% | Specificity: 81% | Specificity: 90% | |
| ATT[44], dB/cm/MHz (mixed etiologies) | 0.62 | 0.67 | 0.73 |
| Sensitivity: 72% | Sensitivity: 87% | Sensitivity: 82% | |
| Specificity: 82% | Specificity: 72% | Specificity: 89% |
1
Individual patient data meta-analysis. In parentheses: etiology of liver disease. CAP: Controlled attenuation parameter; dB: decibel; ATI: Attenuation imaging; MHz: Megahertz; UGAP: Ultrasound guided attenuation parameter; ATT: Attenuation.