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. 2019 Oct 17;4(20):e131355. doi: 10.1172/jci.insight.131355

Figure 12. STAT6 deficiency impairs long-term recovery after tMCAO.

Figure 12

WT and STAT6-KO mice were subjected to 60 minutes of tMCAO. (A) Brain tissue loss 35d after tMCAO was quantified on MAP2-stained (green) coronal sections. n = 8–10 mice per group. Scale bar: 1 mm. (B) Neurological deficit score was assessed during the first 3d after tMCAO. (C and D) Sensorimotor deficits were evaluated with rotarod (C) and foot-fault (D) tests 3d–14d after tMCAO. (E) Cognitive function was assessed with Morris water maze at 21d–25d after tMCAO. Latency to find the hidden platform in the cued test (spatial learning) and time spent in the target quadrant in the probe test (memory) were measured. n = 8–10 mice per group. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001 vs. WT, Student’s t test (A), Mann-Whitney U test (B), or 2-way ANOVA repeated measurement (C–E).