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. 2019 Oct 17;4(20):e124164. doi: 10.1172/jci.insight.124164

Figure 1. mTORC2 is downregulated in infiltrating macrophages in mouse colitis and CAC.

Figure 1

(A and B) IF double staining for F4/80 (green) and (A) pPKCα Ser657 (red) or (B) pAKT Ser473 (red) in mouse control and DSS colitis sections and quantitative number and means of pAKT-positive F4/80 macrophages. Scale bar: 20 µm. (C–E) IF for F4/80 (green) and pPKCα Ser657 (red) (C) or pAKT Ser473 (red) (D and E) in nontumorigenic mouse colon tissue and colorectal tumor sections, and quantitative number and means of pPKCα-positive F4/80 macrophages. Scale bar: 20 µm. A–C evaluated from 4 IF samples. P values were determined by unpaired 2-tailed Student’s t test. **P < 0.01, ***P < 0.001.