Skip to main content
. 2019 Oct 17;4(20):e131712. doi: 10.1172/jci.insight.131712

Figure 2. Agonists for MRGPRA3 and MRGPRC11 evoke mechanical hypersensitivity in colonic afferents.

Figure 2

(A) Application of the MrgprA3 agonist chloroquine (CQ; 10 μM for 5 minutes) resulted in subsequent mechanical hypersensitivity of colonic nociceptors from healthy mice (**P < 0.01, N = 8). (B) The MrgprC11 agonist BAM8-22 (20 μM for 5 minutes) also caused mechanical hypersensitivity in nociceptors from healthy mice (*P < 0.05, N = 8). (C) Application of the combined MrgprC11/MrgprA4 agonist neuropeptide FF (NPFF; 5 μM for 5 minutes) also evoked mechanical hypersensitivity of colonic nociceptors from healthy mice (**P < 0.01, N = 8). Data represent mean ± SEM. P values determined by paired t tests.