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. 2019 Oct 17;4(20):e129240. doi: 10.1172/jci.insight.129240

Figure 7. Perivascular and neuronal association of ASO 24 hours after dosing.

Figure 7

(A) Punctate perivascular staining of ASOs by IHC throughout brain at 24 hours after IT dosing. (B) Colocalization of ASOs and the vascular endothelial marker Reca1 in cerebral cortex (×10 magnification left 2 images, ×40 magnification right image). (C) Colocalization of Cy7-ASO with vascular α-smooth muscle actin (αSMA) and basement membrane component laminin α2 (×20 magnification). (D) Colocalization of ASOs with basement membrane component perlecan (×20 magnification). (E) ASO colocalization with neurons and vessels in cerebral cortex (×10 magnification). (F) ASO colocalization with neuronal cells in hippocampus (×40 magnification).