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. 2019 Oct 17;4(20):e130521. doi: 10.1172/jci.insight.130521

Figure 5. Targeted reversal of microRNA-7a-5p expression in the VMH restores the RH-induced impaired sympathoadrenal response to hypoglycemia.

Figure 5

(A) Blood glucose levels (mg/dL) and (B) glucose infusion rates (GIRs; mg/kg/min) during hyperinsulinemic (20 mU/kg/min) hypoglycemic (40–50 mg/dL for 90 minutes) clamps. Plasma (C) epinephrine (pg/mL), (D) norepinephrine (pg/mL), and (E) glucagon (pg/mL) levels during basal (at 0 minutes) and hypoglycemic periods (30–120 minutes) of hyperinsulinemic hypoglycemic clamps in RS rats treated with intra-VMH aCSF-RS and recurrent hypoglycemic rats treated with either aCSF-RH or control lentiviruses (lenti-7a-cont-RH) or microRNA-7a–encoding lentiviruses (lenti-miR-7a-RH). Data are expressed as mean ± SEM (n = 6–7/group). *P < 0.05, and **P < 0.01 vs. aCSF-RS group; #P < 0.05, and ##P < 0.01 vs. Lenti-miR-7a-RH group; 2-way repeated-measures ANOVA followed by Tukey’s test.