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. 2019 Oct 25;10:1067. doi: 10.3389/fgene.2019.01067

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Copyright © 2019 Zhang, Zhang, Gong, Cui, Ma, Chen, Ai, Xiao, Huang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein-protein interaction network and gene ontology enrichment analysis of candidate genes. (A) Protein-protein interaction network of the 32 most plausible candidate genes of the lead SNPs detected by GWAS and meta-analysis in STRING v10.5 database. (B) Gene ontology enrichment analysis of candidate genes. Over-represented GO/pathway terms were grouped based on kappa statistics. GO/pathway terms are represented as nodes, and the node size represents the term enrichment significance, while the edges represent significant similarity between categories.