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. 2019 Oct 25;10:2394. doi: 10.3389/fpsyg.2019.02394

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Copyright © 2019 Zhang, Meng, Guo, Zhang, Zhang, Chen, Lu, Yang and Xue.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of single prolonged stress (SPS) on anxiety-like behaviors on the first and tenth day after stress. (A) Experimental procedures. (B,C) Time spent in open arms (B) and the entries into open arms (C) in different experimental conditions in EPM. (D,E) Time spent in the central area (D) and total distance (cm) (E) in different experimental conditions in OFT. n = 8 per experimental condition. ^#Different from SPS(1d) group, ^∗Different from NO SPS group at each post-stress day, ^∗ ^#p < 0.05, two-way ANOVA. Data are shown as means ± SEM.