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. 2019 Feb 13;36(Suppl 1):13–19. doi: 10.1007/s12325-019-0885-3

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

PMC Copyright notice

Fig. 1 — CVD development and progression are due to vicious cycles of venous hypertension, inflammation, capillary damage, and edema. From New England Journal of Medicine, Bergan JJ, Schmid-Schonbein GW, Coleridge Smith PD. et al., Chronic Venous Disease, 355., 488–498. Copyright^© (2006) Massachusetts Medical Society.

Reprinted with permission from Massachusetts Medical Society [14]