Table 2.

NASH progression to fibrosis

References	Type	Country	Total study size (n)	NASH stage	Progression (%)
Progression from NASH to fibrosis
Argo et al. [46]	SLR	USA	221	All NASH patients to stage 3/4 fibrosis	15.8% over 3.7 years (mean interval)
				NASH fibrosis patients who progressed to stage 3/4 fibrosis	42.1% over 3.7 years (mean interval)
Musso et al. [49]	Meta-analysis	Not reported	Not reported	NASH to progressive fibrosis	25–30% over 4 years
					50% over 6 years
Sporea et al. [54]	Retrospective cohort study	Romania	478	NASH to severe fibrosis	18.5%a
				NASH to no severe fibrosis	70.8%a
Satapathy et al. [23]	Narrative review	USA	Not reported	NASH to fibrosis	37%a
				NASH to F3 fibrosis	22%a
				NASH to progressive fibrosis	34.5%a
Younossi et al. [19]	SLR	USA	8,515,431	NASH to fibrosis	41%a
Shouhed et al. [53]	Narrative review	USA	Not reported	NASH to fibrosis	26–57%a
Progression from F1/F2 fibrosis onwards
Musso et al. [49]	Meta-analysis	Sweden	Not reported	F1/2 fibrosis to cirrhosis	13%a
Progression from F3 fibrosis onwards
Musso et al. [49]	Meta-analysis	Sweden	Not reported	F3 fibrosis to cirrhosis and end stage liver disease	25%a
Shouhed et al. [53]	Narrative review	USA	Not reported	Fibrosis to cirrhosis	9–17%a

F1/2/3/4 fibrosis stage 1/2/3/4, NASH non-alcoholic steatohepatitis, SLR systematic literature review, USA United States

^aTime frame not reported